The Influence of Administration of Intravenous Clonidine on Dosage of Thiopentone and Cardiovascular Response to Laryngoscopy and Intubation
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 1
Abstract
Introduction: Various techniques and drugs have been used to attenuate the stress response to laryngoscopy and intubation. So the present study was designed to know the influence of intravenous clonidine on dosage of thiopentone and cardiovascular response to laryngoscopy and intubation. Material and Methods: one hundred male patients randomized to two groups belonging to class I and II, Group I (n=50) received 10ml Normal saline intravenously over 120seconds 15minutes before laryngoscopy and intubation. Group II (n=50) received clonidine 2.5μgm/kg intravenously over 120seconds 15minutes prior laryngoscopy and intubation. Values of heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP) and oxyhaemoglobin saturation (SpO2) was recorded before test drug, before induction of anaesthesia (pre-induction), after induction (before airway instrumentation), at the time of laryngoscopy and intubation (T0) and at 1, 3, 5 and 8 minutes after intubation. Results: There was marked increase in HR, SBP, DBP and MAP 1minute following laryngoscopy and intubation in the control group. However, in clonidine group there was a rise in HR, SBP, DBP and MAP values, at 1, 3, 5 and 8minutes after intubation in clonidine group which was clinically not significant though statistically significant. Also there was significant reduction in dose of thiopentone requirement. Conclusion: clonidine in the dose of 2.5μg/kg I.V, given 15minutes before laryngoscopy and intubation can be safely given to attenuate the haemodynamic response to laryngoscopy and intubation without any side effects. Clonidine also reduces the dose of thiopentone requirement to induce sleep during induction.
Authors and Affiliations
Reehan Ahmad, Ram Pal Singh, Gopal Krishan, Malti Agrawal, Vartika Vinay, Siddhartha Hanjura
Keywords
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