The influence of antineoplastic treatment on the weight of survivors of childhood cancer
Journal Title: Jornal de Pediatria - Year 2016, Vol 92, Issue 6
Abstract
Purpose Obesity is a late effect in survivors of childhood cancer and correlates with chronic complications. Survivors of leukemia, brain tumors, and hematopoietic stem cell transplantation are more likely to develop obesity resulting from treatment modalities such as radiotherapy and glucocorticoids. This paper analyzes and integrates the current data available to health professionals in order to clarify strategies that can be used to treat and prevent obesity in childhood cancer survivors. Sources This is a literature review from on scientifically reliable electronic databases. We selected articles published in the last five years and earlier articles of great scientific importance. Data synthesis The mechanisms involved in the pathophysiology of obesity in cancer survivors are not completely understood, but it is believed that damage to the hypothalamus and endocrine disorders such as insulin resistance, leptin resistance, and hormone deficiency may be involved. The body composition of this group includes a predominance of adipose tissue, especially in those undergoing hematopoietic stem cell transplant and total body irradiation. The use of body mass index in these patients may lead to an underestimation of individuals’ risk for metabolic complications. Conclusion Early identification of groups using accurate anthropometric assessments, interventional treatment, and/or preventative measures and counseling is essential to minimize the adverse effects of treatment. Physical activity and healthy eating to promote adequacy of weight in the whole population should be encouraged.
Authors and Affiliations
Luciana Pisani
Keywords
Related Articles
- EP ID EP510590
- DOI 10.1016/j.jped.2016.04.003
- Views 72
- Downloads 0
Influence of the Bolsa Família program on nutritional status and food frequency of schoolchildren
Objective To evaluate the food frequency and nutritional status among students according to participation in the Bolsa Família program funded by the government. Methods Cross-sectional study carried out with students fr...
Preventing hypothermia in preterm newborns – simple principles for a complicated task
Hypothermia is a major contributor to newborn mortality worldwide1,2 and remains a common problem for very low birthweight (VLBW) infants, even in technologically advanced hospital settings.3,4 The attributable risk of m...
Coparenting after marital dissolution and children's mental health: a systematic review
Objective Research has shown that coparenting is a vital family mechanism in predicting mental health in children and adolescents. Considering the increasing prevalence of marital dissolution in Western societies, the ob...
Erratum on “A short form of the neonatal intensive care unit family needs inventory”
In the article “A short form of the neonatal intensive care unit family needs inventory”, published in J Pediatr (Rio J). 2016;92(1):73-80, please consider the following corrections:
Management protocols for status epilepticus in the pediatric emergency room: systematic review article
Objective This systematic review of national or regional guidelines published in English aimed to better understand variance in pre-hospital and emergency department treatment of status epilepticus. Sources Systematic s...