The Influence of Antipsychotic to Decrease the Score of The Positive and Negative Syndrome Scale-Excited Component
Journal Title: Indonesian Journal of Clinical Pharmacy - Year 2018, Vol 7, Issue 1
Abstract
Schizophrenia is a psychiatric disorder with one or more of the following criteria: delusions, hallucinations, ways of thinking and talking that is irregular, behavioral disorders and negative symptoms. The treatment responsed of patients with neurological or psychiatric disorders only be seen from patient’s improved of symptomps and severity decreased that can be measured through doctor’s diagnosis based on instrument measurement such as The Positive and Negative Syndrome Scale-Excited Component (PANSS-EC). The aim of this study were to find out percentage of the antipsychotics selection effect to decrease score of PANSS-EC and to find out which type of antipsychotic that mostly influence the decrease. This study was conducted from January to March 2016 in patients with acute schizophrenia at RSJ (mental hospital) Prof. Dr. Soerojo Magelang using cross-sectional, observational-analytic based on prospective. The difference of pre and post PANSS-EC score of 97 patients were taken randomly as many as 39 patients. Based on the result of one way anova test, the value of significance was 0.021 (p >0.05), linearity F value (0.03), F value counted > F table (2.584 >1.81), which means there was a significant influence between antipsychotics selection with decrease of the PANSS-EC score. The result of Eta association showed that the effect of antipsychotics selection to decrease patient’s PANSSEC score was 73.80%. Based on the result of post hoc anova test, clozapine monotherapy was the most significant antipsychotic therapy with a significance level of 0.05 (mean difference) compared to monotherapy or combination antipsychotics. 73.80% of antipsychotics selection influenced the decrease of patient’s PANSS-EC score, and clozapine was the most siginficant antipsychotic therapy compared to monotherapy or other combination antipsychotics.
Authors and Affiliations
Ayuningtyas G. Purwandityo, Yosi Febrianti, Chynthia P. Sari, Vitarani D. A. Ningrum, Okky P. Sugiyarto
Keywords
Related Articles
- EP ID EP370215
- DOI 10.15416/ijcp.2018.7.1.19
- Views 83
- Downloads 0
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