The influence of cyclosporine A, cyclothiazide and luzindole on the electroconvulsive threshold in mice
Journal Title: Journal of Pre-Clinical and Clinical Research - Year 2007, Vol 1, Issue 1
Abstract
The objective of this study was to determine the effect of cyclosporine A (CSA) (a widely used immunosuppressant drug), cyclothiazide (CTZ) (an inhibitor of desensitization of glutamatergic AMPA receptors) and luzindole (LZ) (an antagonist of melatonin MT2 receptors) on the threshold in the electroconvulsive test in mice. Cyclosporine A and luzindole (up to 50 mg/kg) did not affect this parameter. Cyclothiazide (5-20 mg/kg) dose-dependently lowered the threshold. Our results suggest that cyclothiazide should be avoided in epileptic patients. In contrast to chemically-evoked convulsions, cyclosporine A does not seem to affect electrically-induced convulsions. Finally, the protective action of melatonin is probably not mediated via MT2 receptors.
Authors and Affiliations
Kinga K. Borowicz
Keywords
Related Articles
- EP ID EP58570
- DOI -
- Views 93
- Downloads 0
New approach to Caplan’s syndrome
A combination of rheumatoid arthritis and pneumoconiosis is observed in 2-6% of cases of diseases among people occupationally exposed to either the crystal or fibrous form of silica. Chest radiology of patients affected...
Neuroprotective effects of some newer and potential antiepileptic drugs
Experimental models of epilepsy or [i]status epilepticus [/i](SE) provide evidence that seizures result in diffuse brain damage. Other neurological conditions are also associated with neurodegeneration, for example, stro...
Application of silymarin in human and animal medicine
Silymarin, the polyphenolic fraction from Milk Thistle ([i]Silybum marianum[/i]) and its main component silybinin, are used almost exclusively for hepatoprotection in humans. Silymarin offers good protection in various t...
ECG movement artefacts can be greatly reduced with the aid of a movement absorbing device
Accurate ECG signal analysis can be confounded by electric lead, and/or electrode movements varying in origin from, for example, hiccups, tremor or patient restlessness. ECG signals recorded using either a conventional e...
Resting heart rate variability and plasma noradrenaline level as a measurement of autonomic nervous system activity in mature, aging rats
[b]Introduction and objective.[/b] Aging is a process that also affects the autonomic nervous system (ANS) making it less adaptable to environmental and intrinsic stimuli and affecting its ability to maintain body homeos...