The influence of melatonin and agomelatine on urodynamic parameters in experimental overactive bladder model – preliminary results
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2011, Vol 65, Issue 0
Abstract
Introduction: Overactive bladder (OAB) is a common disease entity with complex pathogenesis that involves neurogenic, myogenic and abnormal paracrine urothelial activity mechanisms. Our objective was to estimate bladder functioning in urodynamic studies in experimental, both acute (AOAB) and chronic (COAB) cyclophosphamide (CYP)-evoked OAB model in response to melatonin (MLT; antioxidant and MT receptor agonist) or agomelatine (AMT; MT receptor agonist and 5HT2C receptor antagonist). Material/Methods: Seven groups were studied: 1 – control, 2–4 – MLT treated AOAB and COAB rats, 5–7 – AMT treated AOAB and COAB rats. AOAB model was evoked by single CYP administration (IP 200 mg/kg body weight), while COAB one was induced by a four-time administration of CYP (IP 75 mg/kg body weight). Each group underwent urethane anesthesia to perform urodynamic recordings in resting conditions and after administration 50 (group 2 or 5), 75 (group 3 or 6) or 100 mg/kg (group 4 or 7) of melatonin (groups 2–4) or agomelatine (groups 5–7), followed by classical urodynamic parameters assessment. Results: Neither melatonin nor agomelatine did not affect urodynamic parameters in the AOAB rats. In COAB model, after 75 and 100 mg/kg of MLT we revealed an improvement in urodynamic parameters. AMT (75 and 100 mg/kg) administration caused deterioration of urodynamic findings suggesting bladder overactivity exacerbation. Disscussion: In summary, melatonin ameliorates bladder overactivity in cyclophosphamide-induced COAB. Agomelatine, contrary to melatonin, aggravates bladder dysfunction in this group. These findings suggest that the improvement in urodynamic parameters after melatonin administration may be due to its antioxidative profile and is not related to MT receptors activation. However, agomelatine’s unfavorable action on the bladder, resulting in its overactivity in COAB group, may not only be the result of MT receptor activation without the concomitant antioxidative effects but may also occur secondarily to co-existing 5HT2C receptor antagonism.
Authors and Affiliations
Łukasz Dobrek, Piotr Thor
Keywords
Related Articles
- EP ID EP66566
- DOI -
- Views 159
- Downloads 0
Mózg i cytokiny – wspólne podłoże depresji, otyłości i chorób układu krążenia?
Coraz więcej badań wskazuje na główną rolę mózgu w regulacji układu krążenia oraz bilansu energetycznego organizmu. W ostatnich latach wykazano, że wspólną cechą chorób cywilizacyjnych, takich jak otyłość, nadciśnienie...
Superfamily of G-protein coupled receptors (GPCRs) – extraordinary and outstanding success of evolution
The G protein-coupled receptors (GPCRs) are considered as very diverse and also surprisingly successful structures during the whole evolutionary process, being capable of transducing the different forms of “information”...
Genetic background of aberrant thermogenin expression (UCP1) in obesity leading to metabolic syndrome
Cardiovascular and metabolic disturbances individually and interdependently lead to chronic pathological conditions observed in cardio-metabolic diseases (CMDs). In Europe, the morbidity and mortality caused by cardiovas...
Fish intake and risk of prostate cancer
The aim of the study was to present the current state of knowledge concerning the relationship between the consumption of fish as materials rich in long chain polyunsaturated fatty acids (LC PUFA) omega-3, and the risk o...
CNC proteins in physiology and pathology
CNC proteins consist of Bach1, Bach2 and 4 homologous transcription factors: Nrf1, Nrf2, Nrf3 and p45NF-E2. Transcription factors belonging to this group of proteins play a crucial role in protection of cells against oxi...