THE INFLUENCE OF RANBP2 MUTATION IN DEVELOPMENT OF INFLUENZA ASSOCIATED WITH ACUTE NECROTIZING ENCEPHALOPATHY IN CHILDREN. CURRENT KNOWLEDGE, AND THERAPEUTIC PERSPECTIVES
Journal Title: European Journal of Pharmaceutical and Medical Research - Year 2019, Vol 6, Issue 8
Abstract
Acute necrotizing encephalopathy (ANE) is amongst the infection related brain complications in which previously healthy children develop rapidly progressive neurological disease within a week following respiratory viral illness. It is a common knowledge that, most ANE are sporadic. However, familial autosomal dominant ANE due to mutations in the RANBP2 gene has been recently reported (ANE1 or infection-induced acute encephalopathy-3 (IIAE3)). Currently, the vast majority of available data are the case report and case series. This comprehensive review adds to the current knowledge of the pathogenesis, influence and the phenotype of ANE caused by mutations in RANBP2 gene.
Authors and Affiliations
Prof. Yinghu Chen MD, PHD Prof. Shiqiang Shang MD, PHD
Keywords
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