THE INFLUENCE OF THE TYPE SOLVENT ON THE STRUCTURE OF CHITOSAN BLENDS WITH HYALURONIC ACID
Journal Title: Progress on Chemistry and Application of Chitin and its Derivatives - Year 2016, Vol 0, Issue
Abstract
The influence of the type solvent on the structure of chitosan, hyaluronic acid and their blend films was investigated. Aqueous acetic acid, hydrochloric acid, sodium chloride and aqueous acetic acid/NaCl were used as solvents for chitosan, hyaluronic acid and Ch/HA solution blends. Ch, HA and their blend films were prepared by casting technique. The homogeneity and morphology of chitosan blends were ascertained from the tapping-mode atomic force microscopy (AFM) and scanning electron microscopy (SEM). The changes of topography images are considered by determining the root mean square (RMS, Rq) deviation in the image data. The surface roughness of chitosan, hyaluronic acid and Ch/HA blended films was altered by mixing. The structure of chitosan blends with hyaluronic acid depends on the blend composition and on the solvent used for preparing the blend.
Authors and Affiliations
Katarzyna Lewandowska, Alina Sionkowska, Sylwia Grabska
Keywords
Related Articles
- EP ID EP190622
- DOI 10.15259/PCACD.21.15
- Views 89
- Downloads 0
EVALUATION OF PHYSICOCHEMICAL PROPERTIES OF SOLID DISPERSIONS OF BCS CLASS II SUBSTANCES WITH CHITOSAN
The BCS class II includes drugs with low solubility and high permeability. The substances require modification to increase their solubility in the upper part of the digestive system. Fenofibrate is an example of this cla...
INFLUENCE OF A CALCIUM ALGINATE ON THE PROPERTIES OF HYDROPHILIC GELS CONTAINING LACTIC ACID COMPLEX WITH CHITOSAN
Treatment of vagina inflammatory condition is usually long and difficult because of its frequent relapse. The investigated preparations on methylcellulose base revealed good adhesion to the vaginal mucosa and were presen...
INFLUENCE OF DIBUTYRYLCHITIN ON HISTAMINE RELEASE FROM MAST CELLS
DBC induces histamine release from mast cells and can modulate function of mast cells in vitro. Histamine excretion from mast cells activated with DBC is considerably lower than for model of anaphylactoid reaction. Modul...
THE INFLUENCE OF A DENTAL FORMULATION PREPARED WITH CHITOSAN ON THE PHARMACEUTICAL AVAILABILITY OF CLOTRIMAZOLE
The present work involves the development of a dental gel composition obtained on the basis of clotrimazole incorporated into chitosan in order to improve drug solubility. Solid dispersions were prepared by using two met...
ISOLATION AND PURIFICATION OF CHITINOLYTIC ENZYMES OF RUMEN CILIATES Eudiplodinium maggii
Results of the earlier studies suggested an involvement of ciliates Eudiplodinium maggii in the digestion and metabolism of chitin in the rumen. In the presented paper we described the results on the preliminary identifi...