The Innate Differences in the Adipocyte Membrane Fatty Acid Composition Could Be Modified By Dietary Fats in Obese Mice
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 6
Abstract
Obesity-related insulin resistance is the risk factor for developing type 2 diabetes mellitus. The fatty acid composition of plasma membrane is known as a mediator to affect insulin action. This study aimed to investigate the differences in the adipocyte membrane fatty acid profile between genetically obese (ob/ob) mice and their lean (+/?) counterparts. In addition, the influence of dietary manipulation with different polyunsaturated/saturated (P/S) fatty acid ratio was also studied. The results showed that ob/ob mice had lower unsaturated (18:1, 18:2) and higher saturated (16:0, 18:0) fatty acids in their adipocyte membranes compared to those of their lean counterparts. Moreover, the unsaturation index of the adipocyte membrane in ob/ob mice that fed a high-fat diet (P/S=0.6) was significantly decreased. In summary, our data indicated that the adipocyte membrane fatty acid composition of ob/ob mice was innately different from their lean counterparts and could be modified by dietary P/S ratio.
Authors and Affiliations
Ming-Der Chen 1,
Keywords
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