The Modulatory Activity of Justicia carnea in Plasmodium Infected Mice
Journal Title: Trends Journal of Sciences Research - Year 2018, Vol 3, Issue 4
Abstract
The study investigated the antiplasmodial potency of Justicia carnea in plasmodium infected mice. The aqueous leaf extract of Justicia carnea was subjected to phytochemical screening using GC-FID. The suppressive, prophylactic and curative activity of the studied plant was accessed after oral administration of standard drugs (5mgkg-1 choroquine and 4mgkg-1 artesunate) and 400-800mgkg-1 of the extract. The effect of the aqueous leaf extract of the studied plant was also explored in the activities of liver enzymes, oxidative stress markers and hematological indices of plasmodium infected mice using spectrophotomertic methods and a hematology auto analyzer (BC 5300 Mindray England) respectively. The aqueous leaf extract of Justicia carnea showed considerable dose dependent antiplasmodial activity in the suppressive, prophylactic and curative test conducted. The suppressive activity of (92%) of the aqueous leaf extract of the studied plant at 800mgkg-1 was comparable to the standard drugs used while the mean survival time of plasmodium infected mice at 800mgkg-1 was beyond the mean survival time of the infected untreated group. The aqueous leaf extract of the studied plant also exhibited significant improvements in the activities of liver enzymes, oxidative stress markers and some hematological parameters at 800mgkg-1 of the extract when compared with the infected and untreated group. The results of the study exhibited the antiplasmodial activity of the studied plant, nonetheless, the crude extracts of the studied plant can be further purified for synergistic use with other potent antimalarial drugs to combat and achieve total clearance of plasmodium resistant infections.
Authors and Affiliations
Alozie S. Chidi, Wegwu O. Mattew, Amadi A. Benjamin, Njoku C. Uche
Keywords
Related Articles
- EP ID EP438993
- DOI 10.31586/Biochemistry.0304.02
- Views 95
- Downloads 0
Fish and Rat as Models to Assess Environmental Toxicity of Silver Nanoparticles
Nano-sized particles of less than 100 nm in diameter are attracting the scientific community due to their wide range of new applications in various fields including biophysics, material and medical sciences. Nanoparticle...
On the Possible Anomaly of Asymmetric Weight Reduction of Gyroscopes under Rotation
In this work, we discuss a theoretical model that can describe novel phenomena of induction of weak anomalous forces in gyroscopes under right rotations either in rest frame of the laboratory or in free-fall. The effect...
The Modulatory Activity of Justicia carnea in Plasmodium Infected Mice
The study investigated the antiplasmodial potency of Justicia carnea in plasmodium infected mice. The aqueous leaf extract of Justicia carnea was subjected to phytochemical screening using GC-FID. The suppressive, prophy...
Bioactivity - Structure. Interrelation of Electronic and Information Factors of Biologically Activity of Chemical Compounds
The biological activity of chemical compounds is analyzed using electronic and information factors. We found a linear interrelation between the electronic and information factors of molecules. Moreover, these molecular f...
Evolutionary Dynamics of Intercoupling of the Chemical Elements in Plants and Primary Soil-Forming Processes
We present the results of a comprehensive long-term experiment on intensive cultivation of wheat and tomato plants to initially abiogenous mineral substrate. The experiment simulates the primary processes of soil formati...