The OPTIMIST study: optimisation of cost effectiveness through individualised FSH stimulation dosages for IVF treatment. A randomised controlled trial
Journal Title: BMC Women's Health - Year 2012, Vol 12, Issue
Abstract
Costs of in vitro fertilisation (IVF) are high, which is partly due to the use of follicle stimulating hormone (FSH). FSH is usually administered in a standard dose. However, due to differences in ovarian reserve between women, ovarian response also differs with potential negative consequences on pregnancy rates. A Markov decision-analytic model showed that FSH dose individualisation according to ovarian reserve is likely to be cost-effective in women who are eligible for IVF. However, this has never been confirmed in a large randomised controlled trial (RCT). The aim of the present study is to assess whether an individualised FSH dose regime based on an ovarian reserve test (ORT) is more cost-effective than a standard dose regime.
Authors and Affiliations
Theodora C van Tilborg, Marinus JC Eijkemans, Joop SE Laven, Carolien AM Koks, Jan Peter de Bruin, Gabrielle J Scheffer, Ron JT van Golde, Kathrin Fleischer, Annemieke Hoek, Annemiek W Nap, Walter KH Kuchenbecker, Petra A Manger, Egbert A Brinkhuis, Arne M van Heusden, Alexander V Sluijmer, Arie Verhoeff, Marcel HA van Hooff, Jaap Friederich, Jesper MJ Smeenk, Janet Kwee, Harold R Verhoeve, Cornelis B Lambalk, Frans M Helmerhorst, Fulco van der Veen, Ben Willem J Mol, Helen L Torrance, Frank JM Broekmans
Keywords
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- EP ID EP679507
- DOI 10.1186/1472-6874-12-29
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