The Pathological Stage at Diagnosis of Breast Cancer in Ghanaian Women: A Retrospective Study at the Korle-Bu Teaching Hospital Accra (2001 to 2014)
Journal Title: Journal of Cancer and Tumor International - Year 2017, Vol 5, Issue 2
Abstract
Background: Published data on breast cancer (BC) in Ghanaian women have not look at the relationships between pathological stage at diagnosis and the other clinico-pathological features. The aim of this study was to describe the relationships between the stage at diagnosis of BC in Ghanaian women and the effects on the other tumours variables. Material and Methods: We reviewed and pathologically staged (I – IV) 1,317 BCs in our institution. Data were collected on the clinico-pathological features of females diagnosed with BC, entered and analysed using SPSS version 23 (Chicago). Results: A total of 1,317 (30.4%) out of 4,336 BCs were pathologically staged using the TNM method and 57.4% were of high stage. The mean ages at diagnosis of BC for TNM stages I – IV were: 50.6, 53.3, 51.0 and 52.2 years respectively. The proportions of women aged less than 40 years for stages I – IV were; 15.6%, 16.0%, 18.3% and 18.8%. Women in all the stages presented after 3 months (late) of noticing the swelling. Skin involvement and high histological grades were commoner in stage IV. The frequency of positive tumour margins and the mean number of positive lymph nodes increases with increasing stage at diagnosis. Conclusion: Women in this study were found to have high pathological stages of BC at diagnosis. The proportions of women less than 40 years old were higher in stages III - IV. Skin involvement, number of positive lymph nodes and positive tumour margins were found to increase with increasing pathological stage at diagnosis.
Authors and Affiliations
E. M. Der, S. E. Quayson, Y. Tettey
Keywords
Related Articles
- EP ID EP308929
- DOI 10.9734/JCTI/2017/33006
- Views 114
- Downloads 0
Can Calcium and Magnesium Infusion before and after Oxaliplatin Administration Improves Its Neurotoxic Effect?
Introduction: The oxaliplatin neurotoxicity is one of two distinct phases: an acute and a dose-limiting cumulative phase. Large doses of I.V Ca & Mg is given before and after oxaliplatin in FOLFOX protocol. Aim: We aime...
Analysis of Pelvic Lymph Nodal Metastasis in Operable Cases of Cancer Cervix-A One Year Cohort Study at a Regional Cancer Centre
Objective: To study the incidence of nodal metastasis in early stage operable cases of cancer cervix and to correlate the nodal metastasis with different parameters like stage, degree of differentiation, lympho-vascular...
Induction Chemotherapy as a Predictor for Definitive Treatment in Bulky Locally Advanced Squamous Cell Carcinoma of the Head and Neck: A Schedule More Suited to Sub Himalayan Region
Purpose: Use of induction chemotherapy (IC) as a predictor for definitive treatment in bulky locally advanced head and neck cancer (LA HNSCC) patients, who are not feasible for any upfront radical treatment in sub-Himala...
Evolutionary Basis of Cancer Metastasis and Its Implication to a Lasting Cure
This review is intended to take us through a journey on how cancer had been treated and highlight the paradigm shift in understanding its treatment since adoption of evolution concept and hope to point to a possible futu...
Primary Breast Lymphoma: A Study of 9 Cases
Aim: Non-Hodgkin's primary lymphoma of the breast is rare. These tumors represent 0.04 to 0.52% of malignant breast pathology, 2.2% of extranodal lymphoma and 0.4% of all non-Hodgkin’s lymphoma. Clinical and radiological...