THE PECULIARITIES OF SPERMATOGENESIS HORMONAL REGULATION IN LABORATORY ANIMALS AFTER ACUTE EXPOSURE OF PELVIS WITH IONIZING RADIATION

Abstract

The research was devoted to studying the post-radiation effects of rat pelvis acute exposure with gamma-rays in the range 1,0 – 7,0 Gy on the peculiarities of spermatogenesis hormonal regulation in the different intervals of post-radiation period lasting 7 – 45 days. It has been shown that the single dose acute gamma-irradiation of sexual organs caused the elevation of pituitary gonadotropins (FSH and LH) in the blood of animals. Simultaneously the raise of es-tradiol concentration concurrently with testosterone blood level abatement was observed. Meanwhile inhibin B and anti-Mullerian hormone tended to decrease compared to control. The development of hormonal disbalance in a said direction enhanced proportionally with the increase of post-radiation period duration and was directly dependent on the radiation dose mean value. Consequently, the established phenomenon attained its maximum manifestation by 45th day of post-radiation period after exposure with gamma-rays in the dose 7,0 Gy.

Authors and Affiliations

L. V. Grubska, I. T. Gavrish, S. M. Kanjuk, A. V. Klepko, I. M. Gudkov

Keywords

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  • EP ID EP399174
  • DOI -
  • Views 98
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How To Cite

L. V. Grubska, I. T. Gavrish, S. M. Kanjuk, A. V. Klepko, I. M. Gudkov (2017). THE PECULIARITIES OF SPERMATOGENESIS HORMONAL REGULATION IN LABORATORY ANIMALS AFTER ACUTE EXPOSURE OF PELVIS WITH IONIZING RADIATION. Наукові праці. Серія "Техногенна безпека", 289(277), 130-135. https://europub.co.uk./articles/-A-399174