The Plasma Homocysteine Concentrations and Relationship with Insulin Resistance in Young Women with Polycystic Ovary Syndrome
Journal Title: Turkish Journal of Endocrinology and Metabolism - Year 2005, Vol 9, Issue 1
Abstract
Women with polycystic ovary syndrome (PCOS) have several cardiovascular disease risk factors including hyperinsulinemia. Hyperhomocysteinemia is a recognized risk factor for atherosclerosis and has recently to be correlated positively with the hyperinsulinemia. We examined the relationship between plasma homocysteine levels and insulin resistance in patients with PCOS. Forty women with PCOS and 35 healthy subjects were studied. Hormonal assays, lipid pofile, homocysteine and fasting insulin levels, insulin resistance indices like HOMA and QUICKI determinations and ultrasound evaluation were performed in all subjects. The mean fasting insulin levels were significantly higher in women with PCOS than control women ( 12.02 ± 7.6 vs 6.08 ± 2.09 μU/ml) where as no difference in fasting glucose concentrations was observed between groups. Insulin resistance indices (HOMA and QUICKI) were significantly different between PCOS and control group (p<0.001). We found significantly higher mean plasma homocysteine concentrations in patients with PCOS as compared with controls ( 11.5 ± 2.71 vs 9.4 ± 1.8 μmol/L, p=0.002). When patients were stratified by body mass index (BMI), the homocysteine concentration were significantly higher in both obese and normal-weight women with PCOS than control women (11.65 ± 2.3, 11.15 ± 1.9, 9.4 ± 1.8 μmol/L, respectively). Fasting insulin concentrations and and insulin resistance indices were significantly different in obese PCOS patients as opposed to normal-weight women with PCOS although both obese and normal-weight PCOS patients were more insulin resistant than normal healthy volunteers. As a result, insulin resistance in women with PCOS is associated with elevated plasma homocysteine, regardless of body weight and together with other risk factors like dyslipidemia or hyperinsulinemia, elevated homocysteine levels may contribute to the risk of cardiovascular disease in women with PCOS.
Authors and Affiliations
Berrin Çetinarslan, Zeynep Cantürk, Erdem Türemen
Keywords
Related Articles
- EP ID EP84400
- DOI -
- Views 105
- Downloads 0
Prevalence of Hepatitis C Virus Infection in Diabetic Patients
In order to evaluate the prevalence of hepatitis C virus (HCV) infection in diabetic patients, 13 type 1 and 106 type 2, a total of 119 diabetic patients were examined. Patients were analyzed for sex, type of diabetes, d...
Risperidon Tedavisi ile İlişkili Diyabetik Ketoasidoz Vakası
Şizofreni ile diyabet arasındaki ilişki daha önceden bilinmektedir. Buna ilaveten bazı vaka takdimlerinde antipsikotik ajanların diyabet gelişimini veya diyabetin şiddetini arttırabildiği gösterilmiştir. 5 aydır risper...
Ghrelin
Growth hormone secretagogues are synthetic peptidyl and non- peptidyl molecules that possess growth hormone releasing activity. Ghrelin is an endogenous natural ligand for the growth hormone secretagogue receptor that ha...
Prevalence of Silent Myocardial Ischemia in Patients with Type 2 Diabetes Mellitus and Related Factors
The aim of the study was to determine the prevalence of silent myocardial ischemia in type 2 diabetic patients without any clinical and/or laboratory findings of myocardial ischemia and to examine the related factors for...
Water and Salt Metabolism Disorders Following Transsphenoidal Pituitary Surgery
Transsphenoidal pituitary surgery is frequently complicated with mild to severe water and electrolyte disturbances in the postoperative period. These disorders are: transient diabetes insipidus, early or delayed hyponatr...