The Platelet/Lymphocyte Ratio in Patients with Ischemic Stroke Treated with Intravenous Thrombolysis and Its Relationship with Mortality, Disability, and Prognosis
Journal Title: Istanbul Medical Journal - Year 2021, Vol 22, Issue 2
Abstract
Introduction: The platelet/lymphocyte ratio (PLR) has been studied frequently to determine the prognosis of cardiovascular diseases, chronic inflammatory diseases, and malignancies. Particularly, the PLR is an indicator of systemic inflammation and atherosclerosis. In this study, we aimed to evaluate the value of the PLR and its relationship with mortality, cerebral hemorrhagic transformation, and short-term prognosis in patients with stroke treated with intravenous thrombolysis. Methods: Two hundred fifty stroke patients treated with intravenous thrombolysis were included in the study. Initial symptoms, comorbidities, and localization of cerebral ischemia were recorded. Disability was scored on the National Institutes of Health (NIH) stroke scale. At the 24th and 72nd hours after treatment, hemorrhagic transformation was evaluated by brain computed tomography. The in-hospital mortality rate was calculated. Patients were divided into groups according to the difference in the NIH stroke scale (between admission and discharge). Serum platelet and lymphocyte levels and PLR values were determined. Results: There were 128 (51.2%) female and 122 (48.8%) male patients included in the study. Their mean age was 71.88±12.36 years. The lymphocyte count was low and the PLR was high in patients with a high level of initial disability (p<0.01). The lymphocyte count was higher in patients with clinical improvement (p=0.023). The lymphocyte count was lower and the PLR was higher in patients who died (p<0.01). The platelet level was lower in patients with hemorrhagic transformation (p=0.024). The lymphocyte level and PLR were similar in the hemorrhagic transformation groups (p=0.156, p=0.675). Conclusion: In this study, it was determined that mortality is related to the PLR, and hemorrhagic transformation is related to platelet levels in patients with ischemic stroke treated with intravenous thrombolysis.
Authors and Affiliations
Fettah Eren, Ayşegül Demir, Güllü Eren
Keywords
Related Articles
- EP ID EP694388
- DOI 10.4274/imj.galenos.2021.89972
- Views 83
- Downloads 0
Evaluation of Factors Affecting the Mortality and Morbidity of Patients with Acute Mesenteric Ischaemia
Introduction: Acute mesenteric ischaemia (AMI) is a disease with high mortality that is not easy to diagnose. It usually develops as a result of arterial obstructions of mesenteric vessels. In this study, we aimed to eva...
The Effect of Different Hemostatic Systems on the Injury of the External Branch of the Superior Laryngeal Nerve in Thyroidectomy
Introduction: Vessel-sealing and ultrasonic coagulation systems that provide rapid and effective hemostasis are widely used in thyroid surgery. An important disadvantage of these systems is injury to the neighboring anat...
Is Sarcopenia Related to Mortality in Patients with Chronic Obstructive Pulmonary Disease in the Intensive Care Unit?
Introduction: On admission to the intensive care unit (ICU), functional and general health stata are important baseline characteristics of critically ill patients with chronic obstructive pulmonary disease (COPD). The me...
Common Findings in Endoscopic Gastric Biopsies in Southeastern Anatolia: Effects of Eating Habits and Helicobacter Pylori Infection
Introduction: Roasted and spicy food (mainly hot pepper) consumption is very common in Southeastern Anatolia. Smoked and spicy diets and Helicobacter pylori (H. pylori) infection are known risk factors for gastric cancer...
Diplopia Due to Orbital Myositis: Diagnosis with Magnetic Resonance Imaging
Orbital myositis is a non-specific inflammatory disease primarily affecting the extraocular muscles. It is most commonly seen in young adults and women and is often unilateral. Periorbital pain, swelling and redness of t...