The PLATFORM Trial: An Insight into the Improved Value of Using FFRCT for Reduction of Invasive Angiographic Procedures
Journal Title: Heart Research – Open Journal - Year 2016, Vol 2, Issue 5
Abstract
Coronary CT Angiography (CCTA) has been widely used as a reliable non-invasive modality for the diagnosis of Coronary Artery Disease (CAD) due to its improved spatial and temporal resolution.1-5For patients with low to intermediate pre-test probability of CAD, CCTA is used as an effective gatekeeper for determination of downstream testing, such as invasive coronary angiography or functional imaging.6However, CCTA is mainly an anatomic test with excellent visualization of coronary anatomical structures and detection of coronary lumen stenosis, while providing little functional information of the coronary lesions. Despite high sensitivity and negative predictive value, CCTA has been reported to have moderate specificity and positive predictive value due to the high percentage of false positive rates, and this is especially apparent in the assessment of coronary arteries with heavy calcification. Studies have shown the limited diagnostic value of CCTA in diagnosing highly calcified coronary plaques.7-11Thus, an imaging technique able to detect ischemia-producing lesions is of paramount importance since coronary stenosis does not always translate to functional significance. Clinical decision making of whether patients should proceed to a revascularization procedure is based on the predictive functional effect of coronary stenosis, because no prognostic benefit of revascularization has been reported in the coronary lesions without functional significance.
Authors and Affiliations
Zhonghua Sun
Keywords
Related Articles
- EP ID EP558683
- DOI 10.17140/HROJ-2-e005
- Views 158
- Downloads 0
Inhibiting the Inhibitors, PTP1B as a Therapeutic Target in Myocardial Infarction
Biological systems self-regulate through cycles of activation and inactivation, the balance of which is critical in permitting or suppressing signaling cascades and their downstream consequences. Kinase signaling pathway...
Coronary CT Angiography in Coronary Artery Disease: from Diagnosis to Prevention
Coronary CT angiography has emerged as reliable imaging tool for the diagnosis of coronary artery disease. Coronary CT angiography has the ability to demonstrate excellent visualization of anatomical changes in coronary...
The Sequelae of Silence: Catheter Entrapment as a Preventable Morbidity Resulting from Communication Failure
Medical errors follow a well-established association with communication failure. Seemingly benign interventions such as central venous catheterization can have far reaching consequences. A 72-year-old male required reope...
Primary Angioplasty Using a Renal Stent in a Severly Ectactic and Occluded Left Anterior Descending Coronary Artery
Revascularization of ectatic coronary arteries in the setting of acute myocardial infarction poses great challenges for the operator. We report a case, where a peripheral renal stent was used successfully to treat the cl...
Writing Thank You Notes after Ophthalmology Residency Interviews?
Objective: To determine the importance of writing thank you notes after ophthalmology residency interviews. Design: Survey. Participants: Ophthalmology residency faculty members. Methods: A short multiple-choice survey u...