THE POTENT ROLE OF SMART CHITOSAN NANOPARTICLES ON ATTENUATION OF TESTICULAR DAMAGE CIMETIDIN –INDUCED IN SWISS ALBINO MICE
Journal Title: European Journal of Biomedical and Pharmaceutical Sciences - Year 2019, Vol 6, Issue 10
Abstract
The present study was carried out to investigate the ameliorative effective of chitosan NPS on testicular damage induced by cimetidine. Mice were randomly divided into 4 groups, the first group served as control group, the second group received oral administration of chitosan NPS 12ml/kg, the third group received oral administration of 400mg/kg cimetidine, and the fourth group received oral co-administration of chitosan NPS and cimetidine. Results showed highly significant increase of prolactin and decrease of testosterone in the group received cimetidine in addition to serve pathological alterations in the testicular tissue represented by increasing tubular area due to elongation of seminiferous tubules disorganization of spermatogonia and absence of the most stags of spermatocytes, with low pathological score, in addition to intense incidence of caspase-3 referred to apoptosis. Where as, co-administration of chitosan NPS with cimetidine resulted in significant decrease of prolactin and increase of testosterone besides to improved testicular tissue with raising pathological score and less appearance of apoptosis.
Authors and Affiliations
Dr. Doaa M. Elnagar
Keywords
Related Articles
- EP ID EP672180
- DOI -
- Views 184
- Downloads 0
KNOWLEDGE AND PRESCRIBING PRACTICE OF PHYSICIANS TOWARD ANTIMICROBIAL RESISTANCE IN HEALTHCARE SETTING, DIYALA, IRAQ
Background: Antimicrobial resistance has increasingly become one of the most critical public health issue. The prescribing behavior of physicians plays a key role in controlling and reduction of antimicrobial resistance....
DETERMINATION OF GLUCODE - 6 - PHOSPHATE DEHYDROGENASE LEVEL AMONG SUDANESE PATIENTS ON HEMODIALYSIS
Background: There is considerable evidence that patients on Hemodialysis are in continuous state of oxidative stress. Glucose-6-Phosphate Dehydrogenase (G6PD) is a cytoplasmic enzyme that protects erythrocytes against ox...
BIOCHEMICAL AND IMMUNOLOGICAL STUDIES ON THE RESPIRATORY DISEASES IN SHEEP IN NORTH WESTERN COAST
Sheep pneumonia remains an important cause of morbidity and mortality worldwide. Here the present study was aimed to investigate the relation between hematological, biochemical, and immunological changes associated with...
ANTIBIOTIC SENSITIVITY PROFILES AGAINST BACTERIA ISOLATES WHICH INFECTING PATIENTS WITH DIABETIC FOOT ULCERS LEVEL 3 AND 4 WAGNER IN PONTIANAK
Diabetic foot ulcer is one of many complications of diabetes. This ulcer can lead to wound infection which happens when a patient has high level of blood glucose. Antibiotic is usually prescribed for diabetic foot ulcer...
APPLICATION OF FORENSIC ENTOMOLOGY TO ESTIMATE POST-MORTEM INTERVAL (PMI) IN MAMMALIAN MODELS IN BANGLADESH
Forensic entomology is used as an important tool to estimate the post-mortem interval (PMI) or time elapsed since death, which is crucial for linking a victim with a suspect in suspicious death case investigations. This...