The prediction antidepressant effects of Chai-Hu-Jia-Long-Gu-Mu-Li decoction by Arrowsmith tool
Journal Title: Drug Combination Therapy - Year 2020, Vol 2, Issue 3
Abstract
Background: To explore the modern pharmacological mechanism of classic ancient prescription of Chinese medicine Chai-Hu-Jia-Long-Gu-Mu-Li decoction and single drug in classic ancient prescription of Chinese medicine Chai-Hu-Jia-Long-Gu-Mu-Li decoction on antidepressant from the theoretical level. Methods: The literature related search tool Arrowsmith was used with the help of Cytoscape drawing software, the relationship between classic ancient prescription of Chinese medicine Chai-Hu-Jia-Long-Gu-Mu-Li decoction and the antidepressant mechanism was analyzed. Results: Different single drugs in classic ancient prescription of Chinese medicine Chai-Hu-Jia-Long-Gu-Mu-Li decoction may play an antidepressant effect by regulating β-catenin, toll-like receptor 4, brain-derived neurotrophic factor, caspase-3, γ-aminobutyric acid A receptor, MAPK, Akt, ERK, AMPK, Wnt, STAT3, CREB, NMDA, iNOS, PKA, matrix metalloproteinase-9, IL-10, ApoE, P38 MAPK, MMP-2, AMPA, PPARγ, TNFα, NF-κB, TGF, CaMKII and EPO. The key antidepressant site is in the hippocampus. Conclusion: The antidepressant effect of classic ancient prescription of Chinese medicine Chai-Hu-Jia-Long-Gu-Mu-Li decoction reflects the action characteristics of multi-components, multi-targets, and multi-pathways of traditional Chinese medicine. Through the search and analysis by Arrowsmith tools, it provides a scientific basis for in-depth interpretation of the antidepressant mechanism and provides research direction and ideas for the research of traditional Chinese medicine compound prescription.
Authors and Affiliations
Ning Mao, Yin-Hai Dai, Zhi-Yong Shao, Mao Wang, Jun-Yi Bai, Qian-Qian Liang
Keywords
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- EP ID EP685185
- DOI 10.12032/DCT2020B023
- Views 169
- Downloads 0
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