The prevalence and clinical characteristics of glucose metabolism disorders in patients with liver cirrhosis. A prospective study
Journal Title: Annals of Hepatology - Year 2012, Vol 11, Issue 2
Abstract
Aims. To define the prevalence and clinical characteristics of glucose metabolism disorders (GMD) in patients with compensated liver cirrhosis (LC). Material and methods. Fasting plasma glucose (FPG) levels were measured to 130 patients with clinically stable LC. Oral glucose tolerance tests (OGTT) and fasting plasma insulin determinations were performed to patients with normal FPG. Insulin resistance (IR) was calculated with HOMA2-IR index. GMD were classified according to FPG and OGTT tests results and to the chronologic relation between diagnosis of diabetes mellitus (DM) and LC as follows: type-2 DM (T2DM), hepatogenous diabetes (HD) and impaired glucose tolerance. Patients from all groups were compared. Results. The prevalence of GMD were as follows: T2DM in 25 patients (19.2%, 95% CI 12.5-25.9), HD in 28 (21.5%, 95% CI 14.5-28.5) and IGT in 36 (38.5%, 95% CI 30.1-46.7). The total of patients with GMD was 79.2% (95% CI 72.3-86.1). In 41% of cases GMD were subclinical and 48.7% of patients had IR. Patients with T2DM had a higher number of variables with significant differences compared with the other groups (more marked compared to the patients without GMD). The only differences between the patients with T2DM and HD were hypercreatininemia: 1.14 ± 0.53 vs. 0.84 ± 0.22 mg/dL (p = 0.005) and family history of DM: 8 (32%) vs. 2 (7%) (p = 0.02). Conclusion. Almost 80% of patients with compensated LC had GMD. Half of them were subclinical. The patients with T2DM had marked clinical differences compared to patients from the other groups, particularly renal impairment.
Authors and Affiliations
Diego García-Compeán, Joel Jáquez-Quintana, Fernando Lavalle-González, Erick Reyes-Cabello, José González-González, Linda Muñoz-Espinosa, Genaro Vázquez-Elizondo, Jesús Villarreal-Pérez, Héctor Maldonado-Garza
Keywords
Related Articles
- EP ID EP78128
- DOI -
- Views 117
- Downloads 0
Akin criteria as a predictor of mortality in cirrhotic patients after spontaneous bacterial peritonitis
Background and aims. Spontaneous bacterial peritonitis (SBP) often triggers acute-on-chronic liver failure (ACLF). Acute kidney injury (AKI) is frequent and correlates with higher mortality in such cases. The aim of this...
Multiple Biliary Hamartomas, The ‘‘Von Meyenburg Complexes’’
-
Detection of hepatitis B activity in HBeAg-negative carriers with normal aminotransferase levels in central Brazil
Background and rationale for the study. Hepatitis B virus (HBV) chronic infection may follow a benigncourse with low risk of cirrhosis or liver cancer. As differentiation of inactive status from HBeAg-negative chronic he...
Promotor methylation: Does it affect response to therapy in chronic Hepatitis C (G4) or fibrosis?
Background and aim. DNA methylation plays a critical role in the control of important cellular processes. The present study assessed the impact of promoter methylation (PM) of some genes on the antiviral response to anti...
The Expression of PNPLA3 Polymorphism could be the Key for Severe Liver Disease in NAFLD in Hispanic Population
Background. Nonalcoholic fatty liver disease (NAFLD) encompasses: fatty liver (SS), steatohepatitis (NASH) with or without fibrosis and cirrhosis. Patatine-like phosphatas in domain 3 (PNPLA3; adiponutrin; SNP rs738409 C...