The probable interspecies transfer of the bla<sub>VIM-4</sub> gene between Enterobacter cloacae and Klebsiella pneumoniae in a single infant patient
Journal Title: Polish Journal of Microbiology - Year 2015, Vol 64, Issue 4
Abstract
We report interspecies transfer of the [i]bla[/i][sub]VIM-4[/sub] gene in MBL-producing [i]Enterobacter cloacae[/i] and Klebsiella pneumoniae isolates from a newborn patient who had received meropenem therapy. We show the evidence that bla[sub]VIM-4 [/sub]gene was transmitted as a part of the class 1 integron on a conjugative plasmid ca. ~90 kb. High homology of nucleotide sequence was observed between the integron found in VIM-4 producing [i]E. cloacae[/i] and [i]K. pneumoniae[/i] strains tested and class 1 integrons previously reported in [i]Pseudomonas aeruginosa [/i]from Hungary and Poland. This finding may suggest[i] P. aeruginosa[/i] as a potential source of the acquired VIM-4 in [i]Enterobacteriaceae[/i].
Authors and Affiliations
Katarzyna Piekarska, Magdalena Rzeczkowska, Tomasz Wołkowicz, Aleksandra Januszkiewicz, Edyta Podsiadły, Urszula Demkow, Rafał Gierczyński
Keywords
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