THE RELATION BETWEEN CA 125, CECT ABDOMEN & PELVIS AND HISTOPATHOLOGICAL FEATURES IN OVARIAN NEOPLASMS
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2019, Vol 8, Issue 3
Abstract
BACKGROUND CA 125 is a glycoprotein and a tumour marker mainly for epithelial ovarian neoplasms. It has potential utility across the spectrum: risk assessment, early detection, prognosis, monitoring and therapy. CT of the abdomen and pelvis is the first line imaging modality for staging, selecting treatment options and assessing disease response in ovarian cancer. The staging CT provides disease distribution, disease burden in the form of peritoneal metastasis, omental deposits or pelvic lymph nodes. Ovary is a complex structure and its neoplasms shows a wide spectrum of histological types and clinical behaviour. The aim of this study was to evaluate the relation between CA 125, CECT abdomen & pelvis and histopathological features in ovarian neoplasms. MATERIALS AND METHODS The present study is an observational study. The study was carried out between February 2018 to July 2018 in dept. of general surgery K. R. Hospital. Inclusion Criteria – all cases of ovarian neoplasms who underwent imaging (CECT) with CA 125, followed by staging laparotomy during the course of study. Exclusion Criteria – all cases of ovarian neoplasms who had received neo adjuvant chemotherapy. RESULTS Out of 80 patients, 24 (30%) were benign and 56 (70%) were malignant. In benign cases 66% were having CA 125 values within normal limits and remaining 34% were having elevated levels. In malignant cases, 7% were having CA 125 within normal limits. CONCLUSION The results of the present study indicate remarkable diagnostic abilities of CA 125 and CECT abdomen and pelvis, in detection of extent of malignant spread of the ovarian disease. It is difficult to suggest a single investigative modality for evaluation of women with ovarian neoplasm. Patients with high level of CA 125 might have advanced stage ovarian neoplasms and are good candidates for neoadjuvant chemotherapy followed by surgery
Authors and Affiliations
Prakash S. S, Charles Jude Antony, Ashwini B. G
Keywords
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- EP ID EP553121
- DOI 10.14260/jemds/2019/41
- Views 74
- Downloads 0
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