The Relation between Serum Homocystiene Level and Recurrent Abortion in Egyptian Women
Journal Title: The Egyptian Journal of Hospital Medicine - Year 2018, Vol 70, Issue 5
Abstract
<strong>Background: </strong>Early pregnancy loss is defined as the termination of pregnancy before 20 weeks' gestation or with a fetal weight of <500 g. Of those that are recognized, 15-<em>20% </em>result in spontaneous abortions (SABs) or ectopic pregnancies. Approximately 5% of couples trying to conceive have two consecutive miscarriages, and approximately 1% of couples have three or more consecutive early pregnancy loss. Increased levels of homocysteine may be due to inadequate dietary intake of folate and vitamin B12 and inherited defects within the methionine-hmocysteine pathway such as MTHFR c677T gene polymorphism. Hyperhomocysteinemia is associated with the syndromes of repeated miscarriage. <strong>Objective: </strong>The aim of the current study is to estimate the serum levels of Homocystine and vitamin B12 and their relation to prevalence of recurrent spontaneous abortion in pregnancies with history of recurrent miscarriage. <strong>Subjects and Methods: </strong>In this study <strong>80</strong> pregnant women classified into two groups: GroupI:<strong>60 </strong>consecutive pregnant women who had suffered from two or more miscarriages, and Group II: <strong>20</strong> pregnant women with no history of abortion .The following estimations were done (for each woman in the study): serum homocysteine and vitaminB12 were estimated using ELISA technique. <strong>Results</strong>: Results showed a significant increase in serum level of homocysteine in the first group compared to control group(p<0.0001) and a low serum level of vitamin B12 which was significantly decreased in the study group (group 1) compared to control group(p<0.0001). Moreover, Our results showed a negative correlation between homocysteine and vitamin B12. <strong>Conclusion:</strong> The elevated serum homocysteine levels during pregnancy were significantly associated with recurrent pregnancy losses. Moreover, reduced serum vitamin B12 level was considered a risk for recurrent miscarriage. Homocysteine is most sensitive and specific<br />parameters in the recurrent pregnancy losses. <strong> </strong>
Authors and Affiliations
Eman Helal
Keywords
Related Articles
- EP ID EP583557
- DOI 10.12816/0043975
- Views 120
- Downloads 0
Comparative evaluation of hemodynamic stability and recovery during conscious sedation by dexmedetomidine with fentanyl versus ketamine with fentanyl in dilatation and curettage
<strong>Background: </strong>Conscious sedation is a technique of providing analgesia, sedation and anxiolysis while ensuring rapid recovery without side effects. Conscious sedation is administered with the dual goals of...
Confidence Levels of Intern Doctors during Root Canal Treatment Procedures in Saudi Arabia
<span>Introduction: </span><span>Endodontic is one of the difficult branches in dentistry as it requires special skills to deals with treatment of the root canals. These difficulties comes from anatomical complexities of...
Role of Positron Emission Tomography/Computed Tomography (PET/CT) in Detection of Bone Metastases
Background and Aim of the Work: Early detection of skeletal metastasis is critical for accurate staging and optimal treatment. Among the various imaging modalities currently available for imaging skeletal metastasis, hyb...
Incidence of Miss Targeting in Frame-based Stereotactic Brain Surgery
Background: accurate localization of a lesion is the ultimate goal of stereotactic surgery. Frame-based systems have the advantage of proven clinical utility and instrument carriage with a high degree of mechanical stabi...
Sex and Age Differences in The Achievement of Control Targets in Saudi Patients with Type 2 Diabetes
<strong>Background: </strong>Diabetes mellitus is a progressive chronic disease with a rapidly increasing prevalence and is associated with significantly high frequency of long-term complications. Despite the scientific...