The relationship between bone mineral density and levels of RANKL, osteoprotegerin and cathepsin-K in patients with rheumatoid arthritis
Journal Title: Dicle Tıp Dergisi - Year 2012, Vol 39, Issue 4
Abstract
Objectives: The aim of this study was to evaluate the levels of osteoprotegerin (OPG), nuclear factor kappa B receptor activator ligand (RANKL), cathepsin K in patients with rheumatoid arthritis (RA) and the relation between these parameters and bone mineral density (BMD). Materials and methods: Totally 90 cases including 30 postmenopausal and healthy women, 30 with postmenopausal osteoporosis and 30 with postmenopause RA were enrolled in the study. The serum RANKL, OPG and cathepsin K were measured by ELISA method. Results: The levels of serum RANKL and OPG in the patients with postmenopausal RA were found significantly higher compared to the postmenopausal healthy women whereas the rate of serum OPG/RANKL was found significantly lower. In addition, the rate of OPG and OPG/ RANKL were significantly lower in patients with postmenopausal RA compared to the postmenopausal osteoporosis, whereas the level of serum RANKL was significantly higher. Positive correlation was detected between bone densities of lumbar spine (LS), femur neck (FN) and the rate of OPG/RANKL in patients with postmenopausal RA. Also negative correlation was detected between LS and FN bone densities and RANKL levels. Conclusions: The system of RANKL/RANK/OPG may have a role in osteoporosis and RA pathogenesis and the rate of OPG/RANKL might be a significant determiner of bone density. Key words: Osteoporosis, rheumatoid arthritis, RANKL, OPG, cathepsin-K
Authors and Affiliations
Gökhan Çakırca, Nuriye Mete, Ibrahim Batmaz, Mustafa Sarıyıldız, Mehmet Ulu, Levent Yazmalar, Tahsin Celepkolu, Remzi Çevik
Keywords
Related Articles
- EP ID EP114551
- DOI -
- Views 87
- Downloads 0
Aile hekimliğine başvuran kadınların sezaryen bilgi düzeyleri: İki merkezli kesitsel bir çalışma
Amaç: Bu çalışmada annelerin sezaryen komplikasyonları hakkında bilgi düzeylerini ve sezaryen olma tercihlerini etkileyen faktörleri inceledik. Yöntemler: Çalışmanın evrenini Yozgat Kadışehri Entegre Devlet hastanesi A...
Determining a Safe Time for Oral Intake Following Pediatric Sedation
Objective: While there are suggestions for oral hydration times after general anesthesia, there is no published study with regard to sedation. The aim of this prospective study was to determine a safe time for oral int...
High school students’ usage behavior and views about mobile phones
Objective: The aim of this study was to determine high school students’ usage behavior and views about mobile phones. Methods: Totally 253 (85.5%) students educated at Honaz High School within the academic year 2010-20...
Home health services in primary care: What can we do?
Home health services is to give examination, diagnosis, treatment, and rehabilitation services to the patients who bedridden, have difficulties to access health facility due to a variety of chronic or malignant diseas...
Sigara kullanıcılarda nikotin bağımlılık düzeyinin yaş ve cinsiyetle ilişkisi: Diyarbakır örneklemi
Amaç: Aile Hekimliği Polikliniğine başvuran hastalardan sigara kullananlara Fagerström nikotin bağımlılık testi (FNBT) uygulanarak elde ettiğimiz nikotin bağımlılık düzeyi ile yaş ve cinsiyet arasında bir ilişki olup ol...