The Relationship between Vitamin D Level and Macrovascular And Microvascular Complications In Type 2 Diabetes Mellitus
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 17, Issue 2
Abstract
Background : The role of Vitamin D deficiency in microvascular complications has been documented. However the effect of vitamin D deficiency on macrovascular complications are not studied extensively. Hence this study evaluate the effect of vitamin D deficiency on both microvascular and macrovascular complications in type 2 diabetes mellitus. Material and Methods : The study was conducted on 200 patients with type 2 diabetes mellitus in which 100 patients are having vascular complications of diabetes(group 1) and 100 patients without vascular complications(group 2). To compare the level of vitamin D, 100 age-sex matched controls without diabetes (group 3) are taken. 25(OH) vitamin D level was measured among all three groups from the serum by ELISA kit. All vascular complications are measured by standard techniques used worldwide. Results : The mean level of vitamin D in group 1 and group 2 and group 3 were 7.53±2.14 and 11.23±3.44 and 31.48±6.43 ng/ml respectively. The 25(OH) vitamin D deficient subjects in group 1 and group 2 and group 3 were 79(79%) and 56(56%) and 14(14%) respectively. The microvascular complications of diabetes mellitus are higher in vitamin D deficiency with vitamin D levels less than 30 ng/ml (P<0.05). The macrovascular complications of diabetes mellitus are also higher in vitamin D deficiency with vitamin D levels less than 30 ng/ml (P<0.05). The number of vascular complications are significantly correlated with vitamin D deficiency severity (p=0.0001) Conclusion : The study gives us an insight to identify the diabetics with vitamin D deficiency which may be at higher risk of vascular complications. Vitamin D deficiency is higher among patients with type 2 diabetes mellitus as compared to controls. Vitamin D deficiency is also higher in patients with type 2 diabetes with vascular complications. Vitamin D deficiency is also associated with severity of vascular complications in type 2 diabetes Further, a need to undertake future prospective multicenter study with larger number of subjects to find a cause effect relationship between vitamin D deficiency and vascular complications in patients of type 2 diabetes mellitus is required. This may help us to initiate interventional studies to see the reversal effect with supplementation of vitamin D to halt the progression of vascular complications and atherosclerosis in patients of type 2 DM. 1. Senior Registrar 2. Junior Registrar, Department of Pathology 3. Principal & Controller, Sr. Professor 4. Medical Officer 5. Professor 6. Assistant Professor 7. Senior Resident
Authors and Affiliations
Kumar M1, Kapuriya S, Agrawal Rp3, Meel Jk4, Sirohi P5, Chahar K, Gadhwal A, Ankit Bs, Phogawat M, Gupta Rk1
Keywords
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- EP ID EP363465
- DOI 10.9790/0853-1702112431
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