The Relationships between SORD -888G>C Gene Polymorphism and Diabetic Retinopathy in a South Sumatran Malay Population
Journal Title: Journal of Research in Medical and Dental Science - Year 2017, Vol 5, Issue 3
Abstract
The sorbitol dehydrogenase (SORD) enzyme has 2 promoter regions with polymorphisms at -1214 C>G (rs2055858) and -888 G>C (rs3759890), which have a complete imbalance, related to gene expression in retinal cells of diabetic patients, and more likely to have a role in diabetic retinopathy (DR) pathogenesis. The SORD -888G>C genotype occurs more often in Japanese DR patients than in patients without complications. A relationship between DR and the G allele in -888G>C polymorphism is observed in Diabetes Mellitus (DM) type- 2 patients. This study aims to elucidate the relationship between the SORD -888 G>C gene polymorphism to the occurrence of DR cases in Malay population in South Sumatra. This is a case-control study. Malay DM type- 2 patients who undergo direct ophthalmoscopy and fundus imaging in the Dr. Mohammad Husein Central General Hospital eye clinic in Palembang, South Sumatra, Indonesia were the subjects of this study. Patient DNA was isolated from blood samples, PCR analyzed and sequenced in order to determine the polymorphism frequencies of the SORD -888 G>C gene. The results showed that every subject had GG genotype in SORD -888 G>C gene promoter. There was no observable polymorphism in SORD -888G>C gene in the authentic Malay population in South Sumatra.
Authors and Affiliations
Ramzi Amin, Faika Novadianaz, Yuwono . , Hikmat Permana, Arief S Kartasasmita, Dany Hilmanto
Keywords
Related Articles
- EP ID EP341958
- DOI -
- Views 144
- Downloads 0
The Effect of Preparation for Hospitalization on School-age Children’s Fear during Admission in Iranian Hospitals
Hospitalization has unpredictable and often negative consequences for children, including fear. The purpose of this study is to determine the effect of preparation for hospitalization on school-age children’s fear during...
Accuration between Sodium and Potassium Serum Levels and Aquoeus Humour in Patient with Senile Cataract
Senile cataract is most commonly type of cataract. Senile cataract patients are estimated to reach 90 % of all cases of cataracts. In patients with senile cataract change the balance of sodium and potassium aqueous humor...
To What Extent Doppler Transvaginal Sonography can be Reliable in Pre and Postmenopausal Women with Abnormal Uterine Bleeding?
The current study was to assess the efficacy of gray scale and power Doppler transvaginal ultrasound in management of patients referred with abnormal uterine bleeding (AUB). This prospective analytical observational cros...
Efficacy of Granisetron on Recovery and Mortality and Morbidity Rate in Acute Pancreatitis
Different treatments for control of symptoms, decrease hospitalization time and costs and reduction of complication and mortality rate of acute pancreatitis are designed and evaluated. Efficacy of serotonin antagonist co...
Postoperative sensitivity after placement of bulk-fill posterior restoration
The purpose of this observational retrospective clinical study was to assess the post-operative sensitivity reported by patients following the placement of bulk-fill composite restorations. Patient records of the seventy...