THE ROLE OF 5-LIPOXYGENASE IN PATHOPHYSIOLOGY AND MANAGEMENT OF NEUROPATHIC PAIN
Journal Title: International Journal of Medical Reviews and Case Reports - Year 2018, Vol 2, Issue 3
Abstract
Neuropathic pain (NP) is a pain caused by lesions in the nervous system. Several causes of NP are traumatic, metabolic disorders, ischemia, toxins, infections, immune-related, and hereditary. The pathophysiology of NP is very complicated and unknown entirely. Therefore the treatment of NP is still unsatisfactory. Recent studies believed the critical role of primary inflammatory mediators in the pathophysiology of NP especially leukotrienes (LTs). The 5-lipoxygenase enzyme (5-LOX) is an enzyme that plays a role in the metabolism of arachidonic acid into LTs. Leukotrienes (LTs) are the essential inflammatory mediators in the pathophysiology of NP. Leukotriene B4 (LTB4) can cause chemotaxis on neutrophils, lowering nociceptors threshold and may contribute to NP. Several studies believed the administration of 5-LOX inhibitors or LTs receptor antagonists could be useful in the management of NP. The purpose of this review is to summarize the involvement of 5-LOX enzyme as an essential role in the pathophysiology and management of NP.
Authors and Affiliations
Pascanus LP Togatorop, Faldi Yaputra, Jimmy Barus, I Putu Eka Widyadharma
Keywords
Related Articles
- EP ID EP533187
- DOI 10.5455/IJMRCR.ROLE-OF-5-LIPOXYGENASE-NEUROPATHIC-PAIN
- Views 117
- Downloads 0
A RARE CASE OF CHRONIC PANCREATITIS COMPLICATED BY INTERNAL PANCREATIC FISTULA AND PANCREATOGENIC ASCITES
Objective: pancreatogenic ascites is rare complication of the chronic pancreatitis associated with a rupture in the ductal system and caused by internal pancreatic fistula. It can become as a result of the chronic pancre...
PRIMARY SQUAMOUS CELL CARCINOMA OF THE THYROID GLAND - CASE REPORT AND REVIEW OF THE LITERATURE
Background Primary squamous cell carcinoma of the thyroid gland (PSCTC) is a rare malignancy, but demonstrates a very aggressive behaviour and has a poor prognosis. The best treatment is radical surgery and postoperative...
EFFECT OF CURCUMA LONGA 0.5% EXTRACT ON SEBUM COMPOSITION AND SKIN MOISTURE IN DRY SKIN PATIENTS
Introduction Dry skin is a problem for millions of people and often causes discomfort and even psychological stress. Curcuma Longa (C. Longa) has been known to have an effect in improving skin texture due to exogenous ef...
Postoperative pain management after craniotomy: Literature review and evaluation of evidence
Background: The effective management of postoperative pain have the tendency to reduce morbidity and mortality. Currently it is becoming clear that appropriate and adequate analgesia is a significant component of post cr...
Neurofilament Light Chain Measurement with Electrochemiluminescence Method (NFL-ECL) in Cerebrospinal Fluid as Promising Diagnostic Method of Amyotrophic Lateral Sclerosis: A Literature Review
ALS is one of the neurodegenerative diseases that have high morbidity and mortality. Beside difficulties to manage, it also has a limited diagnostic method to detect ALS in early onset. Neurofilament Light Chain (NFL) is...