The role of adipokines and gut hormones in the pathogenesis of obesity, and recent findings for the future treatment of
Journal Title: Scientific Journal of Review - Year 2013, Vol 2, Issue 11
Abstract
Obesity has become one of the leading public health concern.Over one billion people are оverweight or obese and the prevalence of theseconditions is growing constantly. This review presents an overview of theendocrine functions of adipose tissue, the role of gut hormones and theirassociated neuronal networks (the gut-brain axis) in appetite control. Recentstudies have improved our understanding of energy homeostasis by identifyingsophisticated neurohumoral networks that transmit signals between the brain andgut to control food intake. Key adipokines, such as, leptin, adiponectin,interleukin-6, рlasminogen activator inhibitor-1, resistin, tumor necrosisfactor-α, adipsin and acylation stimulating protein, macrophages and monocytechemoattractant protein-1, plasma renin, plasma angiotensin - converting enzymeand angiotensinogen linked with pituitary neuropeptide system began to clarify.Gut hormones, such as, сholecystоkinin, ghrelin, peptide YY, pancreaticpolypeptide, glucagon-like peptide-1, оxyntomodulin, ghrelin, insulin,glucagon, obestatin, amylin аre modulated by acute food ingestion. This articlehighlights some of the recent findings and their implications for the futuretreatment of obesity, but there are currently no effective pharmacologicalinterventions for obesity.
Authors and Affiliations
B. ilkovska| PHO Clinical hospital d-r Trifun Panovski Bitola R.Macedonia., B. Kotevska| Tokuda hospital Sofia R.Bulgaria., D. Labudovic| Department of Medical and Experimental Biochemistry, University School of Medicine, Skopje, Macedonia.
Keywords
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- EP ID EP75
- DOI 10.14196/sjr.v2i11.1039
- Views 613
- Downloads 43
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