THE ROLE OF ADIPONECTINE HORMONE IN OBESE WOMEN WITH POLYCYSTIC OVARY SYNDROME ON OOCYTE AND EMBRYO QUALITY AFTER INTRACYTOPLASMIC SPERM INJECTION PROTOCOL
Journal Title: World Journal of Pharmaceutical Research - Year 2017, Vol 6, Issue 12
Abstract
Both Polycystic ovary syndrome and obesity are associated with specific reproduction health complications, including lower oocyte quality and pregnancy rates in assisted conception cycles which may be due to the endocrine- metabolic environment that may influence oocyte quality, and therefore embryo development. Adiponectin is a (Acrp30); 244-amino-acid-long polypeptide. It is an adipose tissue-derived protein whose serum concentrations, in contrast to leptin, are reported to be negatively correlated to body mass. Adiponectin had beneficial effects on the reproductive processes and an important relationship with the gonadotropins and other hormones. Objective: To determine the effect of adiponectine hormone in serum and follicular fluid in obese women with polycystic ovary syndrome and patients at day of ova pick up in assissing oocyte and embryo quality after intra_ cytoplasmic sperm injection. A total of 45 infertile obese women (30 women with Polycystic ovary syndrome and the other 15 women as a control-not PCOS) undergoing intracytoplasmic sperm injection cycle were prospectively recruited for this study in High Institute of Infertility and Assissted Reproductive Technology, Al-Nahrin University, Baghdad-Iraq; during the period from octobar 2016 to the end of February 2017. All patients underwent a long or short standard gonadotrophin releasing hormone agonist protocol(GnRH-a). Serum and follicular fluid of adiponectine levels were measured on the day of oocyte retrieval using by Enzyme linked immuno sorbent assay. The concentration of serum and follicular fluid of adiponectine hormone was showed no significant differences between the polycytic ovarian syndrome and control group (P>0.05); however the serum level of the adiponectine hormone showed slightly decrease in polycystic ovary syndrome patients than in control patients(506.67 ± 42.74, 522.18 ± 44.01) ng/ml respectively. The concentration of Luteinizing hormone level in serum was highly significant increase in polycystic ovary syndrome patients than in control (7.823 ± 0.33, 3.717 ± 0.51) IU/ml respectively. The mean number of oocyte retrieved, mature oocyte(MII) were significantly increase in polycystic ovary syndrome patients than in control patients. We can conclude that the level of adiponectine hormone at day of oocyte retrieval in both serum and follicular fluid, has not have the benefit role in determination the quality of the oocyte and embryo after intra cytoplasmic sperm injection cycles.
Authors and Affiliations
Riham Saad Khdhim
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