The role of endothelin-1 and nitric oxide affecting endothelial dysfunction in the etiopathogenesis of ischaemic heart disease
Journal Title: International Journal of Clinical Biochemistry and Research - Year 2018, Vol 5, Issue 4
Abstract
Introduction Endothelial dysfunction is an imbalance in bioavailability ofendotheliumderived relaxing Nitric Oxide and contracting factors Endothelin Studies have shown that NO has antiatherogenic property as it inhibits vascular smooth muscle contraction and proliferation platelet aggregationand leukocyte adhesion On the other handEndothelin1 causes proliferationand vasoconstriction of myocytes resulting in elevated vascular tone thereby contributing to endothelial dysfunction This dysfunction is a wellestablished response to cardiovascular risk factors and precedes the development of atherosclerosis As a result status of an endothelial dysfunction may reflect the propensity to develop atherosclerotic disease and may serve as a marker of an unfavourable cardiovascular prognosisMaterials and Methods 50 cases of angiographically proven ischemic heart disease and 50 age and sex matched patients with no evidence of ischaemic heart disease on angiography were selected from GB Pant Hospital New Delhi India Serum levels of Endothelin were estimated by sandwich ELISA and nitric oxide levels by modified Griess reactionResults Serum levels ofEndothelinwere raised while nitric oxide levels were significantly reduced p0049 in the cases as compared to controls The mean plasma nitric oxide level in the study group cases was 23511348 M and in the control group was 29351573 M The difference between the two was significant p0049 The mean plasma endothelin level in the study group was 304137fmolml and in the control group was 295170 fmolml The difference between the two was not significant p 0764Conclusion Higher Endothelin1 and lower NO levels in cases suggest their role in causing endothelial dysfunction in ischemic heart disease patients However larger sample size is required to assess the role ofEndothelinas a biomarker of endothelial dysfunction in patients of ischemic heart diseaseKeywords Endothelial dysfunction Endothelin1 Nitric oxide Ischemic heart disease Atherosclerosis
Authors and Affiliations
Arpita Suri, Ritu Singh, Sanjay Tyagi, J Bhattacharjee
Keywords
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- EP ID EP475426
- DOI 10.18231/2394-6377.2018.0114
- Views 66
- Downloads 0
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