The Role of Fibrin Glue for Splenic Salvage in Grade I and II Splenic Injuries in Albino Rats and Rabbits
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 9
Abstract
Introduction: Spleen is one of the most commonly injured abdominal organ in blunt trauma. Iatrogenic splenic injury accounts for 20% of all splenectomy. A better understanding of importance of the spleen, its role in immune response and increased awareness of "post splenectomy sepsis" syndrome has led to the concept of splenic salvage surgery. Thus this experimental study was done to assess the role of fibrin glue for splenic salvage in grade I and II splenic injuries in albino rats and rabbits Method: In this study, 60 healthy albino rats and 20 rabbits were used. All albino rats were randomly divided into three groups and rabbits into two groups. Laparotomy was done in all groups and superficial lacerations were made, then fibrin glue application or splenorrhaphy or no intervention was done according to different groups. Observation: In rabbits all were show healing, there was no difference between the fibrin glue and splenorrhaphy group (P>0.05). There was higher grade of adhesion in higher grade of tear and the difference was statistically significant (P<0.05). In rats, 3 of the 20 rats (15%) in the control group without intervention showed no healing while all of the 20 rats (100%) in the fibrin glue & splenorrhaphy group respectively healed. Even in rats the difference between the 3 groups was not statistically significant (P>0.05). Conclusion: Splenorrhaphy and fibrin glue application had no significant difference in healing. Splenorrhaphy had significantly more and higher grades of adhesions than fibrin glue application. Grade of adhesions increased with increasing grade of tear in both rats and rabbits.
Authors and Affiliations
Dr Ashutosh Silodia
Keywords
Related Articles
- EP ID EP515128
- DOI -
- Views 80
- Downloads 0
Thyroid Status in Patients with Menstrual Abnormalities: A Prospective Study
Introduction: Menstrual abnormalities are one of the common causes of consultations in obstetrics and gynecology outpatient department. Abnormalities of thyroid function has been found to be associated with various menst...
Study of Treatment Outcome in Diabetes Mellitus Patients Receiving Directly Observed Treatment Short course (DOTS) for Pulmonary Tuberculosis in Kanyakumari Government Medical College and Hospital: A Retrospective Study
Background: Tuberculosis if untreated, the disease may be fatal within five years in 50%-65% of cases. More than 5.7 million new cases of TB were reported to WHO in 2013.About 95% of cases from developing countries. Mult...
A Prophylactic Phenylephrine Infusion for Preventing Hypotension during Spinal Anaesthesia for Caesarean Section and to Study its Effects on APGAR Score and Umbilical Artery Blood pH
BACKGROUND: Hypotension after spinal anaesthesia for caesarean section is a common complication. The usual approach to use vasopressors in this clinical setting is reactive rather than proactive; spinal anaesthesia induc...
Ultrasonographic Evaluation of Foetal Hydronephrosis
Objectives: Hydronephrosis is commonly detected during routine ultrasound examination of antenatal mothers. There are multiple conflicting prognostic factors in the available literatures with no clear focus on the postna...
Probiotics and antisecretory agents though costly are effective alone in mild to moderate non bacterial acute gastroenteritis
Objectives: To evaluate the utilization of Probiotics and Racecadotril for the patients of acute gastroenteritis (AGE) and subsequently their health outcome at an Infectious Disease Hospital and to observe the relationsh...