The role of finasteride on perioperative bleeding in patients undergoing TURP: A randomized controlled study
Journal Title: International Archives of Integrated Medicine - Year 2016, Vol 3, Issue 10
Abstract
Background: Benign prostatic hyperplasia (BPH) is the commonest urological condition affecting men over 50 years of age. Medical therapy is usually the first line management of BPH. Finasteride is a 5-alpha reductase inhibitor (5ARI), which blocks the conversion of testosterone into the more potent dihydrotestosterone (DHT). Materials and methods: We prospectively enrolled 54 BPH patients with prostate size ranging from 30-60 gm based on ultrasound, who were undergoing elective TURP at Gandhi Hospital for a period of 2 years from January 2013 to Jan 2015. BPH patients with hematuria, bothersome symptoms and refractory retention were included in the study. Results: Totally 54 BPH patients were enrolled in our study, 30 were randomized to finasteride group and 24 to controlled group. There was significantly less (p value <0.01) mean blood loss in irrigation fluid in the finasteride group compared to the control group (54.27 gm in finasteride group Vs 82.45gms in the control group; p value < 0,01) for each transurethral resection of prostate. Conclusion: Finasteride give daily for 2 weeks before transurethral prostate resection decreased bleeding preoperatively, thereby decreasing the requirement of blood transfusions, post operative episodes of hematuria and clot retention.
Authors and Affiliations
G. Mallikarjuna, N. Ramamurthy, Ravi Jahagirdar, Dr. Jagadeeshwar
Keywords
Related Articles
- EP ID EP502353
- DOI -
- Views 121
- Downloads 0
Langerhans Cell Histiocytosis: Story of The Orphan Disease Beyond Dermatology
Langerhans cell histiocytosis (LCH), a rare proliferative disorder of cells that share phenotypic characteristics with dermal Langerhans cells, has long been considered an “orphan,” or neglected disease. Prior to its cur...
Giant Schwannoma of upper eye lid in a male child of 13 years – A rare case report
Isolated Schwannoma of the eyelid is an extremely rare benign neoplasm. Although it is believed to be present from birth, it show accelerated growth during the childhood or later in adults. These are generally asymptomat...
Evaluation of etiopathological factors of intestinal obstruction and methods of prevention in a tertiary care hospital
Intestinal obstruction is an emergency condition which when unrelieved at the earliest will lead to strangulation and gangrene of the bowel. The aim of this study was to find the various causes for small intestinal obstr...
Maternal and Perinatal Outcome in Premature Rupture of Membranes at Term Pregnancy
Background: Before onset of labour if premature rupture of membranes occurs, then it is called premature rupture of membranes. This study was conducted to evaluate the maternal and perinatal outcomes in term PROM cases....
Correlating multi-detected computed tomography findings with conventional radiography, operative and histopathological examination in mandibular swellings
Introduction: Mandibular swelling are common entity in dental and general surgery practice requiring prompt intervention, imaging techniques such as plain radiography and especially multi-detector computed tomography (MD...