The role of histopathological examination, therapeutic difficulties and thromboembolism treatment during palliative chemotherapy in patient with antithrombin deficiency , colon cancer and endometrial cancer
Journal Title: OncoReview - Year 2017, Vol 7, Issue 1
Abstract
Palliative chemotherapy in patients with thrombophilia is a challenge for clinical oncologists. On one hand the optimal treatment should be very safe for patient, on the other hand – as effective as possible. That therapy is also connected with proper thromboprophylaxis. The incidence of multiple cancers is a serious problem of modern oncology. In patients whose medical history includes two or more cancers, it is essential to obtain histopathological diagnosis before the administration of treatment of disseminated disease. It allows to avoid improper therapy which is often toxic. The article presents the case of a patient with antithrombin deficiency and two cancers in medical history: colon cancer and endometrial cancer. The treatment of the patient because of the metastatic cancer was started after the histolpathological diagnosis. In metastatic lymph node the endometrial cancer was recognized. The carboplatin and paclitaxel were used in the therapy. The treatment was conducted in four course chemotherapy. It revealed considerable polyneuropathy and hematologic toxicity limiting from further therapy. Treatment allowed to obtain biochemical response, decrease of metastases and the condition of a patient improved. During the systemic therapy thromboprophylaxis with acenocumarol was used. The incidence of venous thromboembolism (VTE) or bleeding complications were not noticed.
Authors and Affiliations
Katarzyna Kryszczyszyn-Musialik, Ludmiła Dolczak, Grzegorz Słomian
Keywords
Related Articles
- EP ID EP187861
- DOI -
- Views 223
- Downloads 0
Nasopharyngeal carcinoma – treatment possibilities in patients with primary metastatic carcinoma
This article presents methods of effective treatment of primary metastatic nasopharyngeal carcinoma, both causative and symptomatic, taking into account possible available treatment therapies (chemotherapy, targeted ther...
Dermatofibrosarcoma protuberans (DFSP) – advances in diagnostics and therapy
Dermatofibrosarcoma protuberans is a rare soft tissue sarcoma with a superficial growth. It has an estimated incidence of 4 cases per one million persons per year. DFSP is preferentially located on the trunk. It can appe...
Mięsaki tkanek miękkich i kości oraz GIST – relacja z konferencji naukowej: ESMO Conference on Sarcoma and GIST, 9–10 marca 2012, Mediolan, Włochy
W dniach 9–10 marca 2012 r. w Mediolanie (Włochy) odbyła się konferencja naukowo-szkoleniowa zorganizowana przez Europejskie Towarzystwo Onkologii Medycznej (ESMO, European Society of Medical Oncology) poświęcona mięsako...
Targeted therapies in neuroendocrine neoplasms
The primary treatment of gastrointestinal neuroendocrine tumors is surgery, and its extent depends on the clinical stage of cancer. In advanced disease medical therapy is used. One possible form of treatment is biologica...
Zaburzenia psychiczne u chorych na nowotwory - podejście kliniczne
Pacjent z chorobą nowotworową nie tylko mierzy się z chorobą pierwotną, ale także narażony jest na stany emocjonalne, które przy niesprzyjających warunkach i dużym obciążeniu mogą prowadzić do depresji, zwiększonego lęku...