The Role of Inflammatory Mediators in the Pathogenesis of Alzheimer’s Disease
Journal Title: Sultan Qaboos University Medical Journal - Year 2015, Vol 15, Issue 3
Abstract
Alzheimer’s disease (AD), a neurodegenerative disorder associated with advanced age, is the most common cause of dementia globally. AD is characterised by cognitive dysfunction, deposition of amyloid plaques, neurofbrillary tangles and neuro-inflammation. Inflammation of the brain is a key pathological hallmark of AD. Tus, clinical and immunopathological evidence of AD could be potentially supported by inflammatory mediators, including cytokines, chemokines, the complement system, acute phase proteins and oxidative mediators. In particular, oxidative mediators may actively contribute to the progression of AD and on-going inflammation in the brain. Tis review provides an overview of the functions and activities of inflammatory mediators in AD. An improved understanding of inflammatory processes and their role in AD is needed to improve therapeutic research aims in the feld of AD and similar diseases.
Authors and Affiliations
Gholamreza Azizi| Department of Laboratory Medicine, Imam Hassan Mojtaba Hospital, Alborz University of Medical Sciences, Karaj, Iran, Research Center for Immunodefciencies, Children’s Medical Center, Shadi S. Navabi| Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran, Ahmed Al-Shukaili| Health & Social Services Sector, Te Research Council Oman, Muscat, Oman, Mir H. Seyedzadeh| Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran, Reza Yazdani| Research Center for Immunodefciencies, Children’s Medical Center, Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran, Abbas Mirshafey| Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
Spinal Neurofbroma Masquerading as a Herniated Disc A case report
We present the only case in English medical literature of a spinal neurofbroma misdiagnosed as a herniated disc using magnetic resonance imaging (MRI). Tis case presented with typical symptoms and radiological fndings...
Effects of Pre-Pregnancy Body Mass Index and Gestational Weight Gain on Low Birth Weight in Omani Infants A case-control study
Objectives: Tis study aimed to investigate the association between pre-pregnancy maternal body mass index (BMI), gestational weight gain and low birth weight (LBW) in babies born to a sample population of Omani women....
Perceptions of the Use of Blueprinting in a Formative Theory Assessment in Pharmacology Education
Objectives: Tis study aimed to assess perceptions of the use of a blueprint in a pharmacology formative theory assessment. Methods: Tis study took place from October 2015 to February 2016 at a medical college in Gujura...
Enemy within? The silent epidemic of substance dependency in GCC countries
THE USE OF NATURALLY OCCURRING MOOD- altering substances is deeply rooted in the traditions and cultures of many communities worldwide. As documented in other societies and historical records,1,2 various compounds have...
Evidence Based Health Care A scientific approach to health care