The role of lapatinib in HER2-positive breast cancer
Journal Title: OncoReview - Year 2013, Vol 3, Issue 2
Abstract
HER2 positive breast cancer presents 25–35% of newly diagnosed cases and is associated with more aggressiveness and poorer prognosis. The anti-HER2 monoclonal antibody trastuzumab improved the outcome of women with HER positive breast cancer. Despite the primary effectiveness resistance to trastuzumab occurs. The second drug which interacts with HER2 receptor is lapatinib. There is no cross resistance between both drugs. Lapatinib is dual, reversible tyrosin kinase inhibitor of epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor type 2 (HER2). Based on the results of the clinical trials the efficacy and safety of lapatinib was confirmed.
Authors and Affiliations
Małgorzata Kuc-Rajca, Tadeusz Pieńkowski, Anna Walaszkowska-Czyż
Keywords
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