The Role of Serotonin in the Development of Experimental Diverticulosis
Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2019, Vol 19, Issue 3
Abstract
Diverticulosis was simulated by creating a local depression in the wall of the intestine of rats by creating a vacuum of 0.1 atm at the distal portion of the cecum. Studies of the role of serotonin in the development of experimental diverticulosis was carried out by preliminary administration of serotonin at a dose of 100 mg / kg. It was demonstrated that serotonin enhances the contractile activity in experimental colon diverticulosis during the first 10 days from the beginning of simulation and has koloprotective actionIn the pathogenesis of diverticular disease (DD) and a number of other intestinal diseases, intestinal innervation disorders are of great importance, accompanied by impaired motor function [1]. These phenomena are based on both a weakening of the inhibitory effects of the cerebral cortex on the lower parts, with a significant decrease in the reactivity of the sympathetic division of the autonomic nervous system and a decrease in the level of neurotransmitter catecholamines, and an increase in the blood content of biologically active substances - serotonin (5-hydroxytryptamine, 5-HT) . Serotonin is an important regulator of intestinal secretion and motility [2-4]. More than 95% of serotonin is deposited in the intestine, where 5-HT is synthesized by enterochromaffin (EC) cells. Serotonin-containing cells make up about 70% of the total endocrine cell population. Enteroendocrine cells, the ratio of which may vary, contain 5-HT and numerous peptides that regulate the motor, secretory and sensory activity of the intestine in physiological concentrations [5,6]. Serotonin is secreted by EC cells of the mucosal lamina in response to mechanical, chemical and other stimuli [2], and the release of 5-HT is the main trigger of peristalsis, secretion and signaling of visceral sensitivity [7].
Authors and Affiliations
AM Puzikov, GS Mikhailyants, AE Lychkova
Keywords
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- EP ID EP621818
- DOI 10.26717/BJSTR.2019.19.003310
- Views 171
- Downloads 0
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