The role of stem cells in the improvement of brain injuries after hypoxic ischemia
Journal Title: Electronic Physician - Year 2012, Vol 4, Issue 2
Abstract
Introduction: Nowadays, the important role of stem cells in treatment of many diseases such as stoke is well known. Stem cells derived from either bone marrow or cord bloods are good sources for tissues replacement after post embryonic injuries. Methods: Fourteen-day-old Wistar rats were used in this study. Rats were subjected to internal carotid artery occlusion for 30 minutes. Then, animals were received intravenously 2×105 Bromo Deoxy Uridine (BRDU) labeled- cord blood stem cells (CBSCs). Rats with hypoxic conditions that were not received any injection were assumed as a sham group. Intact animals who did not receive any injection or surgeries were used as a control group. Results: Our results were evaluated according to behavioral tests and immunohistochemistry of the brain especially frontal cortex of the control, sham and experimental groups. Behavioral recovery was observed in the experimental group compared to the either the sham or the control group. In addition, histological studies demonstrated a reduction in ischemic cells in the experimental group compared to the sham group. Conclusion: Intravenous transplantation can be a future line in treatment of infants with hypoxic who are exposed to irreversible damages.
Authors and Affiliations
Mohammad Reza Nikravesh , Mehdi Jalali , Hossein Ali Ghafaripoor, Javad Sanchooli , Darioush Hamidi, Shabnam Mohammadi , Masoomeh Seghatoleslam
Keywords
Related Articles
- EP ID EP87946
- DOI -
- Views 123
- Downloads 0
Assessment of the prevalence of occupational accidents and their influential factors in an electricity distribution company during a five-year period
Background: Occupational accidents have been considered as one of the most important crippling factors contributing to disabilities and life-threatening situations in many countries. This study was conducted to survey th...
Comparison of the effect of topiramate versus gabapentin on neuropathic pain in patients with polyneuropathy: A randomized clinical trial
BACKGROUND: Neuropathic pain is one of the most common complaints of neurologic clinics. Neuropathic pain is common and important and has inappropriate complications, and despite their importance, there is no effective t...
Epilepsy as a health problem among school children in Turaif, Northern Saudi Arabia, 2017
BACKGROUND: Epilepsy is the most common serious neurological disorder and is one of the world's most prevalent non-communicable diseases. There are no recently published data on the prevalence of epilepsy in school child...
Effect of diode laser irradiation on compressive strength of dental amalgam
INTRODUCTION: One of the biggest disadvantages of dental amalgam is that gaining its ultimate strength is a slow process. The use of a rapid-setting amalgam with high early compressive strength could be a better option i...
Effectiveness of supplementary blended flour based on chickpea and cereals for the treatment of infants with moderate acute malnutrition in Iran: A randomized clinical trial
BACKGROUND: Despite the decreasing rate of under nutrition children in recent years overall, the negative affect in growth and development make it as a main concern in the world. Applying an available and appropriate sup...