The Study of Antioxidant and Antibacterial Properties of Skin, Seeds and Leaves of The Sri Lankan Variety of Pumpkin
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2018, Vol 8, Issue 2
Abstract
Reactive oxygen species and free radicals are implicated in numerous disorders, diseases as well as in the aging process. Natural antioxidants in the form of raw extracts or chemical constituents are sort after in order to combat destructive processes due to oxidative stress. The antioxidant and antibacterial activity of acetone, ethyl acetate and methanol extracts of skin, leaves and seed of the Sri Lankan variety of Cucurbita maxima was investigated. The ethyl acetate extracts of leaves gave the highest rate of change of reducing power with concentration (0.1625 ml/mg) in Fe3+ reducing power assay and the highest rate of change of radical scavenging activity with concentration (7.016 ml/mg) during DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging assay. The highest hydroxyl radical activity was observed in methanol extract of seeds (82.7±3.0 %). The Folin-Ciocalteu assay showed the highest phenol content in the ethyl acetate extract of leaves (526.2±2.0 mg (PGE)/g). The highest flavonoid content was in the acetone extract of leaves (35.0±0.5 mg (QE)/g).The methanol and acetone extracts of skin and ethyl acetate extract of seed showed antibacterial activity against Staphylococcus aureus. Methanol extract of skin and ethyl acetate extract of leaves showed activity against Bacillus subtilis.
Authors and Affiliations
D M R H Dissanayake, Srianthie A Deraniyagala, C M Hettiarachchi1 ,, G Thiripuranathar2
Keywords
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