The Study of Prevalence of Pulmonary Hypertension in Children with Sickle Cell Disease
Journal Title: Pediatric Education and Research - Year 2019, Vol 7, Issue 1
Abstract
Objective: To assess the prevalence and the risk factors of pulmonary hypertension in children with sickle cell disease. Methods: Children (age: 3- 15 y) diagnosed with sickle cell disease were included in the study conducted between August 2016 to July 2018. All relevant past history of hospitalisation, crisis (esp. acute chest syndrome crisis), blood transfusion and medication history was recorded. A thorough physical examination, blood investigations (CBC and Reticulocyte Count) and 2D Echocardiography was carried out for all the enrolled patients. Results: In this study, 18.57% of the study population was found to have PAH with TRV > 2.5 m/s. No statistically significant co-relation was found between age, gender, religion, anthropometry, blood group type, sickle phenotype, total leukocyte count and PAH. There was a statistically significant association of pulmonary hypertension with low Hb, high reticulocyte count and platelet count, history of repeated hospital admissions and blood transfusions and a positive history of ACS.It was also found that patients who were on hydroxyurea treatment were less likely to develop PAH. Conclusion: One-fourth of pediatric sickle cell disease patients demonstrated presence of pulmonary hypertension. Risk factors like low Hb, elevated platelet and reticulocyte count, repeated number of hospital admissions, episodes of ACS and blood transfusions were significantly associated with an elevated TRV finding on Echocardiography in children with Sickle Cell Disease. Hydroxyurea therapy too played a significant role in this study in reducing the chances of having PAH. These patients need to be monitored and followed-up after treatment to assess need for later treatment
Authors and Affiliations
Sonal Gore
Keywords
Related Articles
- EP ID EP649344
- DOI 10.21088/per.2321.1644.7119.2
- Views 105
- Downloads 0
Clinical Profile of Hypoxic- Ischemic Encephalopathy in Neonates with Birth Asphyxia in a Rural Tertiary Care Hospital in Central India
Context- Perinatal asphyxia and Postasphyxial hypoxic-ischemic encephalopathy (HIE) is a major cause of early neonatal mortality in India accounting for 24.3% of neonatal deaths. Aim- To study risk factors, clinical, bi...
Clinical Correlates of Working Memory Deficits in School Going Children with and Without ADHD in Ahemdnagar
Both working memory and attention-deficit/hyperactivity disorder (ADHD) have been associated with educational deficits. Since working memory deficits are prevalent in children with ADHD, the main aim of the present study...
Nutrient Consumption among Tribal and Non Tribal Children
Introduction: Nutritional status refers to the health of an individual as it is determined by the intake of nutrients and their utilization. Food consumption is one of the major factors determining nutritional status of...
Outcome of Convulsive Status Epilepticus in Children: A Cross Sectional Study
Background: Convulsive status epilepticus (CSE) is the most common neurological emergency in children and often associated with poor outcome. A prospective cross sectional study was done on 193 north Indian children with...
Rebound Hyperbilirubinaemia Following Intensive Phototherapy
This prospective study was conducted in tertiary care hospital attached to Department of pediatrics, Mahadevappa Rampure Medical college Kalburgi. Aims: To determine the incidence of post phototherapy rebound hyperbilir...