The study of PS biocomplex as a promising antimicrobial preservative in compositions of medicinal and cosmetic products
Journal Title: ScienceRise: Pharmaceutical Science - Year 2017, Vol 0, Issue 3
Abstract
Aim. Research of efficiency of PS biocomplex as an antimicrobial preservative in composition of medicinal and cosmetic products, as well as determination of its active concentration as a preservative in emulsion systems of various types. Methods. Methods of information search, literature data analysis, microbiological and technological methods were used. Results. To study preserving ability of PS biocomplex and to compare its activity with the known preservatives, emulsion-type bases o/w and w/o were used. Ten emulsions of each type with different concentration of PS biocomplex were developed, as well as its consistent use with parabens, sodium benzoate, benzalkonium chloride and silver nanoparticles. PS biocomplex in studied concentrations ranging from 0.025 % to 0.1 % shows effectiveness as a preservative. However, in concentrations of 0.025 and 0.05 % it can be used as a preservative only in w/o emulsions type with low content of aqueous phase. The use of PS biocomplex in concentration of 0.1 % meets pharmacopoeial criteria to the effectiveness of antimicrobial preservatives for emulsions of both types. The simultaneous use of PS biocomplex with other preservatives can reduce the concentration of the latter in of emulsion products composition, due to increase of preserving activity of the studied emulsions. Conclusion. Results of research of PS biocomplex preserving activity show prospects of its further study as an antimicrobial preservative aiming to implement in of medicinal and cosmetic products manufacture, that will help to expand the range of excipients for skin application products
Authors and Affiliations
Iryna Pelekh, Nadia Dilai, Svitlana Bilous, Rosa Vildanova, Oleksandr Shulha
Keywords
Related Articles
- EP ID EP647978
- DOI 10.15587/2519-4852.2017.103442
- Views 153
- Downloads 0
Research of socio-psychological characteristics of pharmacy specialists
<p>The <strong>purpose</strong> of the article is to study the socio-psychological characteristics of Ukrainian pharmacists.</p><p><strong>Methods</strong><strong>:</strong> methods of psychodiagnostic analysis, expert a...
Standardization parameters of modified extracts from leonurus cardiaca herb
<p>To date, in Ukraine there are 8 combined herbal medicines of Leonurus cardiaca registered in Ukraine, 10 national enterprises produce tincture of it and 3 national manufactures pack it herb. Tincture of Leonurus cardi...
Розробка методики кількісного визначення фенольних сполук у пижма квітках
<p>Великий асортимент сировини дикорослих лікарських рослин використовують для лікування та виготовлення препаратів на їх основі, однією із таких є пижмо звичайне. Обмежена кількість лікарських препаратів пижма на вітчиз...
Study of the inulin complex of dahlia root bulbs of Ken's flame species and its standardization
<p>The literature data analysis has shown that phytopolysaccharides are perspective sources for study and development of active pharmaceutical ingredients, and can be used as new medicines or biologically active additive...
Синтез та протимікробна активність амідів 3-бензил-5-метил-4-оксо-2-тіоксо-1,2,3,4-тетрагідротієно[2,3-d]піримідин-6-карбонової кислоти
<p><strong>Мета.</strong> Цілеспрямоване отримання нових протимікробних засобів серед похідних 2-тіотієно[2,3-d]піримідин-6-карбонових кислот.</p><p><strong>Матеріали та методи дослідження.</strong> У роботі використовув...