The survival and KRAS/BRAF testing in colorectal cancer: a review on the literature of Iran
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2016, Vol 4, Issue 5
Abstract
Colorectal cancer (CRC) is the third most common cancer and the fourth leading cause of cancer death and incidence rates of CRC are highest in Australia, New Zealand, Europe, and North America and lowest in Africa and South-Central Asia. The aim of this study was a retrospective analysis of patients hospitalized in the Clinic of Hematology and Oncology, Kermanshah, Iran, between 2002 and 2014. One hundred eighty-six CRC patients referred to our Clinic and data analysis for sex and age was performed using IBM SPSS.v19 and also survival was plotted by Kaplan-Meier plot and Log-rank test in Graph Pad prism 5 Software in a five-year period with two-year follow-up and DNA extracted by FFPE QIAGEN kit and KRAS were analyzed by applying allele-specific PCR X7 primers (ARMS method) and DXN scorpion and ARMS assay for detection of BRAF mutation V600E and pyrosequencing. The mean age at diagnosis was 54.27±13.24 years (range, 22 to 84 years) that 55.4% were males. The 5-year survival rate and mean were 84.61% and 41 months, respectively. Of 186 patients with CRC, 24 patients (12.9%) had metastatic CRC (62.5% KRAS wild type, 20.8% KRAS mutation in codon 12 and etc.). In conclusion, there was no the relationship between sex and age in patients, but the survival rate for females was higher than males and it was statistically significant (P<0.05) and also KRAS wild- type is more than KRAS mutations in patients with metastatic CRC in western Iran. Keywords: BRAF, Colorectal Cancer, KRAS, Survival
Authors and Affiliations
Mehrdad Payandeh, Masoud Sadeghi, Sakineh Ghorbani, Shaban Moradi
Keywords
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