The translation elongation factor 1A in tumorigenesis, signal transduction and apoptosis: review article.
Journal Title: Amino Acids - Year 2004, Vol 26, Issue 4
Abstract
An increasing number of evidences suggest the involvement of the eukaryotic elongation factor 1A, a core component of the protein synthesis machinery, at the onset of cell transformation. In fact, eEF1A is shown to be up-regulated in cell death; moreover, it seems to be involved in the regulation of ubiquitin-mediated protein degradation. In addition, eEF1A undergoes several post-translational modifications, mainly phosphorylation and methylation, that generally influence the activity of the protein. This article summarizes the present knowledges on the several extra-translational roles of eEF1A also in order to understand as the protein synthesis regulatory mechanisms could offer tools for cancer intervention.
Authors and Affiliations
A Lamberti, M Caraglia, O Longo, P Arcari
Keywords
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