The use of metformin versus insulin in the management of diabetes mellitus in pregnancy a randomized control trial
Journal Title: Journal of the Indian Medical Association - Year 2018, Vol 116, Issue 6
Abstract
The Primary objective was to determine whether metformin given to pregnant women with diabetes mellitus during antenatal period until delivery effectively control blood sugar in comparison to insulin or not. Secondary objective was to determine the pattern of association of adverse pregnancy outcome including incidence of pregnancy induced hypertension, preeclampsia, Caesarean section, postpartum haemorrhage, maternal weight gain during pregnancy and incidence of the baby’s admission to the neonatal unit. In this study, of the 80 women assignment for metformin, 90.6% continued to receive metformin until delivery and 48.3% received supplemental insulin. The rates of other outcomes did not differ significantly between the groups. There were no serious adverse events associated with the use of metformin. The numerical variables were compared between the two groups by the students independent sample T test or Mann Whitney test as appropriate, Chi-square test or Fisher exact test has been employed for intergroup comparison of categorical variables.
Authors and Affiliations
Subesha Basu Roy, Shilpa Basu Roy, Hajikul Alam, Subhankar Chowdhury, Sudip Kumar Saha
Keywords
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