The value of measuring trace elements and oxidative/antioxidant factors in umbilical blood in predicting the onset and evaluation of neonatal respiratory distress syndrome
Journal Title: Journal of Clinical Pediatrics - Year 2025, Vol 43, Issue 3
Abstract
[Objective] To determine the trace elements and oxidative/antioxidant factors in cord blood of premature infants, and to clarify their value in predicting the onset and evaluation of neonatal respiratory distress syndrome (NRDS). [Methods] Premature infants with gestational age less than 34 weeks who were hospitalized in the neonatal department from Dec. 2022 to Dec. 2023 were selected as the subjects. The levels of trace elements were determined by flame atomic absorption spectroscopy, and the levels of oxidative factor malondialdehyde (MDA) and antioxidant factor superoxide dismutase (SOD) were measured by surface linked immunosorbent assay. The differences in the above indicators between the NRDS group and the control group were compared. The value of each indicator in predicting the onset of NRDS were determined by the receiver operative curve (ROC). [Results] The cord blood copper levels and zinc levels in the NRDS group were significantly lower than those in the control group. The SOD level in the NRDS group was lower than that in the control group, and the MDA level was higher than that in the control group. Meanwhile, the SOD/MDA ratio in the NRDS group was significantly lower than that in the control group. The area under the curve of zinc, copper, SOD, MDA, and SOD/MDA in cord blood predicting the onset of NRDS were 0.728, 0.917, 0.627, 0.780, and 0.824, respectively. [Conclusions] The decrease in levels of trace elements copper and zinc in cord blood and the imbalance of oxidative/antioxidant factors are involved in the pathogenesis of neonatal respiratory distress syndrome.
Authors and Affiliations
Jing HUANG, Xiaochen LIU, Xiong GAO, Xiaowen LI, Guanghong LI, Luquan LI
Keywords
Related Articles
- EP ID EP763264
- DOI 10.12372/jcp.2025.24e0424
- Views 7
- Downloads 0
Progress in the research of infantile fiberoptic bronchoscopy sedation
The use of fiberoptic bronchoscopy (FB) in pediatrics has been established over several decades, as an invasive airway procedure, FB is crucial for diagnosing and treating tracheal and pulmonary diseases in children. How...
Progress in multidisciplinary diagnosis and treatment of spinal muscular atrophy
Spinal muscular atrophy (SMA) is a rare autosomal recessive disease of progressive, symmetrical proximal limb and trunk muscle weakness and atrophy caused by degeneration of motor neurons in the anterior horn of the spin...
Predictors of recurrent febrile seizures during the same febrile illness in children with febrile seizures
[Objective ] This study aimed to identify the risk factors associated with the recurrence of seizures during the acute phase of febrile seizures (FS) in children. [Methods ] A retrospective analysis of FS patients treate...
Analysis of RSV prevalence dynamics and mixed positivity for other pathogens among children in Suzhou before, during and after the COVID-19 pandemic
[Objective] To understand the prevalence of respiratory syncytial virus (RSV) and co-positivity of other pathogens before, during and after COVID-19 pandemic, and to provide evidence-based support for improving the preve...
Clinical and genetic characterization of 7 pediatric cases with PRKAG2 cardiac syndrome
[Objective] To investigate the clinical and genetic characteristics of PRKAG2 cardiac syndrome (PCS) in Chinese pediatric patients. [Methods] A retrospective analysis was conducted on the clinical data and genetic testin...