Thrombocytosis as a Significant Indicator of Prognosis of Renal Cell Carcinoma
Journal Title: MedPulse -International Medical Journal - Year 2016, Vol 3, Issue 7
Abstract
Background: Various prognostic factors have been studied to predict the survival of renal cell carcinoma (RCC) during last decades. In many types of malignancies, thrombocytosis has been reported and studied as a prognostic factor. The objective of present study was to evaluate the significance of thrombocytosis in determining prognosis in patients with localised RCC who underwent radical nephrectomy. Material and methods: The study included 100 consecutive patients. Patients were divided into a normal platelet count group (group A) and a thrombocytosis group (group B) according to the preoperative platelet count. Thrombocytosis was defined as a platelet count greater than 450,000/mm3. The data about stage distribution, grade, tumor size, histological subtype, hemoglobin level, Body Mass Index (BMI), age, gender, and survival rate of tumors between these two groups were compared. Results: The mean age of the patients was 58.9 years and the mean follow-up period was 52.7 months. Of these 100 patients, 19 had a preoperative platelet count greater than 450,000/mm3 (group B). The mean age of the patients with thrombocytosis was 56.4 7.79 years compared with 61.58.29 years in patients with normal platelet counts (p<0.05). Thrombocytosis was noted in 7 (10.93%) of 64 patients with stage pT1-T2 disease and in 12 (30%) of 36 patients with stage pT3-T4 disease. Patients with thrombocytosis had a worse prognosis than patients without thrombocytosis. Conclusion: The platelet count can be considered a useful prognostic factor in patients with RCC who undergo radical nephrectomy.
Authors and Affiliations
S Suresh
Keywords
Related Articles
- EP ID EP207457
- DOI -
- Views 130
- Downloads 0
ECG changes in patients of acute cerebrovascular diseases
Introduction: Numerous studies have demonstrated the fact that primary neurologic abnormalities may produce ECG changes without any myocardial lesion. ECG changes affecting T wave, U wave, S-T segment, Q-T interval and a...
Primary Breast Tuberculosis mimicking malignancy
Breast tuberculosis is an uncommon form of entity, usually presenting as abscess or lump rarely it presents at hard lump mimicking malignancy. A 40‑ year old female, presented with a lump in the right breast in sub areol...
A study of role of thrombocytopenia in the prognosis of the patients with malaria
Introduction: Thrombocytopenia is an early and consistent feature of malaria, but its pathogenesis remains incompletely understood. In falciparum malaria there is increased platelet consumption as evidenced by shortened...
Clinical profile of intracranial space occupying lesions of brain
This study is a study of ICSOL admitted in department of medicine GMCH Aurangabad. In this study detail clinical examination of all cases done with contrast CT in each cases. As per the clinical and radiological criterio...
Unusual presentation of pulmonary nocardiosis as pyopneumothorax in case of pemphigus vulgaris
Nocardia is a partially acid fast, gram positive bacteria. Its microbiological appearance mimicks that of mycobacterium tuberculosis, hence it gets misdiagnosed on many occasions. It very commonly inflicts immunocompromi...