Thyroid dysfunction in relation to treatment modality in type II diabetes mellitus patients
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 17, Issue 2
Abstract
: Hypothyroidism and diabetes share clinical sign and symptoms, such as fatigue, lethargy and weight gain. Thyroid hormones and insulin exert their metabolic effects which are similar in some respects but antagonistic in others, Insulin inhibits glycogenolysis, glycolysis as well as glucogenesis. Whereas thyroid hormones has a stimulating effects on this action. Aims and Objectives: To study the effect of oral hypoglycaemic agents (OHA) and Insulin on thyroid profile of type II diabetes mellitus patients. Methods: It was a cross sectional study done on type 2 diabetes mellitus patients. 100 cases and 50 controls were included in the study. Diabetic patients on medication that alter thyroid functioning, patients with previously known thyroid dysfunction & pregnant women were excluded from the study. Detailed history was taken; physical examination and required investigations were conducted on patients who satisfied inclusion & exclusion criteria. Investigations done were fasting Plasma glucose, TSH, FT3 and FT4. Differences between various parameters were considered statistically significant when the p value was <0.05. Results: Prevalence of abnormal thyroid function test results was higher in the insulin-treated patients than in those receiving only oral hypoglycaemic agents (OHA) (30.64% vs. 21.05%). Conclusions: the prevalence of thyroid dysfunction was found to be more in the patients who were on both oral hypoglycaemic agents and insulin than the patients who were only on oral hypoglycaemic agents The present study shows that the prevalence of thyroid dysfunction is high in type 2 DM patients on treatment with insulin, hence regular monitoring of TSH levels in such patients should be suggested. -
Authors and Affiliations
Dharmendra Kumar, Sumegha Rana2
Keywords
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- EP ID EP361706
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