Thyroid Dysfunction in Women during First Trimester of Pregnancy: Correlation with Anti-Thyroid Peroxidase Antibodies
Journal Title: Scholars International Journal of Biochemistry - Year 2019, Vol 2, Issue 2
Abstract
Background: During pregnancy, thyroid dysfunction has been associated with a number of adverse outcomes. The presence of anti- Thyroid Peroxidase Antibody (anti-TPO) also results in post-partum complications. Hypothyroidism is closely associated with the presence of anti-TPO. The study aimed to evaluate anti-TPO and thyroid function tests in first trimester of pregnancy. Materials and Methods: The study was carried out at Department of Biochemistry, Medical College and SSG Hospital, Vadodara, Gujarat, India over a period of one year after prior approval from institutional ethics committee. Total 200 normal pregnant women in their first trimester were randomly selected after informed written consent. Women having known thyroid dysfunction, other endocrinopathies, undergone thyroid surgery or taking thyroid medications were excluded. Overnight fasting blood samples from participants were analyzed for anti-TPO, thyroid stimulating hormone (TSH), total T3 and total T4. Results: Mean maternal age was 25.56 ± 3.32 years. Out of 200, total 30 (15%) pregnant women of first trimester had TSH level >2.5 mIU/l. Out of these 30 females, 9 (4.5%) had overt hypothyroidism & 21 (10.5%) had subclinical hypothyroidism. Among these 30 hypothyroid women, 26 (13%) had found anti-TPO positive (anti-TPO >35 IU//ml) which also showed a significant positive correlation with TSH level and negative correlation with T3 and T4 level. Conclusion: Hypothyroidism especially sub-clinical hypothyroidism is prevalent among pregnant women with positive correlation with anti-TPO. It is suggested that anti-TPO should be added as a screening test in first trimester of pregnancy which can be useful to identify early thyroid dysfunction.
Authors and Affiliations
Vanaraj Diyora, Tejas Shah, Mritunjay Kumar Mishra
Keywords
Related Articles
- EP ID EP509541
- DOI -
- Views 72
- Downloads 0
Are Iron Deficiency Anaemic Patients Prone To Cardiovascular Disease?
The property of iron to get reversibly oxidized and reduced is essential for its metabolic functions. Severe iron deficiency can produce cardiovascular disease. Wide range of biochemical markers are implicated in the pat...
Fast, Accurate and Cost-Effective Detection and Diagnostics of Diabetes Mellitus Thanks to Using New, Patented Diagnostic Procedure and Clinical Expert Decision Support System Bio Analyst
The main aim of this study is to present a new, effective approach to diagnose Diabetes Mellitus in a timely, accurate and cost-effective manner, thanks to using technology and new, patented diagnosing procedure. This st...
Hydrochloric Acid Pretreated Agro Wastes as Carbon Source on CM-Cellulases Production by Aspergillus Niger
Main objective of this study is to utilize Agro wastes instead of pure sugars for cellulases productions. It was noted that maximum fungal cell growth was obtained 0.936g/100ml of Aspergillus niger was observed at pH 4.1...
Cytokine System Reactivity of the Rats’ Brain at Intrabulbar Injection of β-Amyloid Aggregates
Neuroinflammation, mediated by the reactivity of the system of cytokines, accompanies the flow of amyloidosis in Alzheimer’s disease, alongside with disturbances in the work of central departments of the olfaction analyz...
Study on Lupus Pattern of Dyslipidemia in Systemic Lupus Erythematosus
This study aimed to find a lupus pattern of dyslipidemia in Systemic Lupus Erythematosus (SLE).Thirty SLE cases and thirty age matched controls are included in this study. Fasting venous blood was collected and base line...