Tissue distribution of gold nanoparticles after single intravenous administration in mice.
Journal Title: Pharmacological Reports - Year 2013, Vol 65, Issue 4
Abstract
Nanoparticles (a part of matter which size is less than 100 nm) have numerous potential applications in biomedicine, due to their unique surface, electronic and optical properties. The goal of the present study was to examine the distribution of gold nanoparticles (GNPs) in mice after single intravenous administration.
Authors and Affiliations
Marek Wojnicki, Magdalena Luty-Błocho, Joanna Knutelska, Jacek Sapa, Małgorzata Zygmunt, Gabriel Nowak, Krzysztof Fitzner
Protoporphyrin IX induces apoptosis in HeLa cells prior to photodynamic treatment.
Photodynamic therapy (PDT) combining treatment with a light-excited compound and laser light induction, via cellular ROS generation, kills cancer cells by damaging organelles and impairing metabolic pathways. As the exac...
Adaptive vasoactive response to modulatory effects of endothelin-1 in spontaneously hypertensive rats.
In addition to a direct vasoconstrictor effect, endothelins modulate vascular responses induced by different mediators.We compared the effect of subthreshold concentrations of endothelin-1 (ET) on vasoreactivity of isola...
Involvement of adenosine receptors in dizocilpine-induced motor activity in mice.
The effect of adenosine receptor ligands on dizocilpine-induced locomotion was studied in mice. Dizocilpine-induced hyperactivity (0.1 mg/kg ip) in mice was antagonized by all adenosine receptor agonists: CPA - A(1) rece...
Cytochrome P450-dependent metabolism of omega-6 and omega-3 long-chain polyunsaturated fatty acids.
Dietary fish oil omega-3 fatty acids (n-3 PUFAs), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), protect against arrhythmia and sudden cardiac death using largely unknown mechanisms. EPA and DHA may...
Commonly used ryanodine receptor activator, 4-chloro-m-cresol (4CmC), is also an inhibitor of SERCA Ca2+ pumps.
4-Chloro-m-cresol (4CmC) is an extensively used activator of ryanodine receptors (RyRs). Studies have shown that 4CmC, at a concentration of 1 mM, is sufficient to cause Ca(2+) release through RyRs. Here, we show that mM...