To compare efficacy of 10-day sequential triple therapy versus14-days sequential therapy for the eradication of H. pylori.
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH IN MEDICAL SCIENCES - Year 2017, Vol 3, Issue 3
Abstract
Background: Helicobacter pylori (H.pylori) colonization is the main main risk factor for peptic ulceration as well as for gastric adenocarcinoma and gastric MALT (mucosa-associated lymphoid tissue) lymphoma. Till date optimal therapeutic regimen has not been defined for H.pylori eradication, so present study is being conducted to compare efficacy of 10-day sequential triple therapy versus 14-days sequential therapy for the eradication of H. pylori. Methods. Four hundred H. pylori positive patients (diagnosed by rapid urease test and histology), were randomized to receive 10-day sequential therapy as follows with Omeprazole (20 mg) plus Amoxicillin (1g) twice⁄day for five days, followed by Omeprazole (20 mg) with Tinidazole (500 mg) twice⁄day and Clarithromycin (500 mg) twice⁄day for five consecutive days and 14 Days Sequential Therapy with Omeprazole (20mg bid), Amoxicillin (1gm bid) for seven days, followed by Omeprazole (20mg) with Clarithromycin (500mg) and Tinidazole (500mg twice/day) for seven consecutive days respectively. Eradication rates were determined four weeks after treatment by rapid urease test. Results. Though the eradication rate was 80 % and 86 in 10 days sequential therapy group and 14 days sequential therapy group respectively, there was no statistically significant difference in eradication rates in these two groups (‘p’value>0.05). Conclusions. 14 days Sequential therapy group had better eradication rates as compared to 10 days Sequential therapy group but results were not statistically significant when both the groups were compared together.
Authors and Affiliations
Shiv Charan, Rakesh Aggarwal, Gurminder Singh Sudanshu Garg, Robin Garg, N. S. Neki
Keywords
Related Articles
- EP ID EP550093
- DOI 10.22192/ijcrms.2017.03.03.013
- Views 163
- Downloads 0
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