To compare the safety and efficacy of diacerein and oxaceprol in the management of grade I & II osteoarthritis of knee
Journal Title: Indian Journal of Pharmacy and Pharmacology - Year 2018, Vol 5, Issue 3
Abstract
Introduction Diacerein and oxaceprol are frequently used for the treatment of GradeI II osteoarthritis of knees Diacerein acts by blocking the action of interleukin1 whereas oxaceprol prevents leukocyte infiltration in the synovial joints Both the drugs are effective But there are few comparative studies regarding safety and efficacy of these two drugs Hence we planned this studyMaterials and Methods An open label randomized comparative study was conducted by the departments of Pharmacology and Orthopedics at Dr RPGMC Tanda HP after taking permission from the IEC Patients were diagnosed clinically as per American College of Rheumatology ACR guidelines and graded radiologically as Grade I II osteoarthritis of the knee joint based on Kellgren and Lawrence classification Then considering exclusion criteria patients were enrolled after taking written informed consent 31 and 29 patients were enrolled in diacerein and oxaceprol groups respectively Tab diacerein 50 mg and oxaceprol 200 mg were prescribed twice daily for three months in respective groups One patient dropped out in each group who opted for operative intervention after a few days of enrolment Efficacy was assessed clinically by WOMAC scale during their follow up at three months Safety was evaluated clinically considering adverse effects and by complete haemogram blood biochemistryResults In diacereingroup WOMAC score mean SD improved from 4877 1817 to 2940 1994 pvalue 000001 and in oxaceprol group from 4259 1949 to 2658 1683 pvalue 000001 No adverse effect was reported in any groupConclusion Both medicines are almost similar in safety and efficacyKey words Diacerein Oxaceprol Osteoarthritis of knee
Authors and Affiliations
Dinesh Kansal, Satyendra Sharad, Vipin Sharma, Parveen Sharma
Keywords
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- EP ID EP478554
- DOI 10.18231/2393-9087.2018.0023
- Views 107
- Downloads 0
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