To determine if lower dose of propofol is as good as standard dose of propofol for laryngeal mask airway insertion after premedication with midazolam and fentanyl.
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 3
Abstract
Purpose: To determine if lower dose of propofol is as good as standard dose of propofol for laryngeal mask airway insertion after pre-medication with midazolam and fentanyl. Background: Propofol is routinely used for induction of general anesthesia and facilatiting laryngeal mask airway insertion. However, heavy doses may lead to severe complications, whereas lower doses may not be quite as effective. Methods: In a double blind randomized controlled trial, 140 patients undergoing ambulatory surgeries lasting less than 2 hours were recruited to receive intravenous propofol at a dose either 1 mg/kg (Group I) or 2.5 mg/kg (Group II). Intravenous midazolam (0.04 mg/kg) and fentanyl (1 mcg/kg) were used as pre-medication in all patients. After pre-oxygenation with 100% oxygen with appropriately sized facemask, anesthesia induction was initiated. Haemodynamic parameters, LMA insertion score, duration of apnoea, probable complications and number of attempts of LMA insertion were compared between two groups. Results: The systolic blood pressure, diastolic blood pressure, mean arterial pressure was significantly higher in Group I than Group II (p value 0.003, 0.004, 0.03). There was no significant difference in heart rate and saturation via pulse oximetry (p value >0.05). LMA insertion was successful in first attempt in all patients of both groups. The duration of apnoea was significantly higher in group II than group I (p value 0.0001). Conclusion: Propofol in a dose of 1 mg/kg can be safely used for LMA insertion in patients pre-medicated with midazolam and fentanyl. It provides satisfactory LMA insertion conditions. This lower dose is associated with better hemodynamic stability and shorter duration of apnoea.
Authors and Affiliations
Dr. Chhavi Goel, Dr. Rajat Garg, Dr. Anand Sharma, Dr. Sangeeta Khanna
Keywords
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- EP ID EP365894
- DOI 10.9790/0853-1703013442
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