To Evaluate the effect of Dexmedetomidine Pretreatment on Myoclonus during Anaesthetic Induction with Etomidate
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 4
Abstract
Etomidate is frequently used nowadays as an inducing agent in patients with compromised cardiovascular function, but it leads to undesirable side effects like myoclonus during induction. Several drugs have been considered before induction to reduce the incidence of myoclonus. This prospective, randomized double blinded study was aimed to compare the effect of dexmedetomidine (DEX) pretreatment on the incidence and severity of etomidate-induced myoclonus. 100 patients undergoing elective surgical procedures were randomly allocated to two groups for i.v. administration of 1.0 µg/kg DEX in 100 mL isotonic saline (group D) and 100 mL isotonic saline (group NS) 10 minutes prior to induction. All groups subsequently received 0.3 mg/kg etomidate by intravenous injection. The incidence and severity of myoclonus were recorded for 1 min after etomidate administration and the incidence of cardiovascular adverse effects were also recorded. The incidence of myoclonus was 38% was in group D and 70% in group NS. The severity of myoclonus was graded as mild, moderate and severe. In group D and group NS number of patients who had mild, moderate and severe myoclonus were 10,5,4 and 11,15,9 respectively. It was concluded that pretreatment with 1.0 µg/kg DEX significantly reduced the incidence and severity of etomidate-induced myoclonus during anesthetic induction.
Authors and Affiliations
Dr. Priyanka Dixit
Keywords
Related Articles
- EP ID EP493315
- DOI -
- Views 73
- Downloads 0
Comparative Study of Hemodynamic Responses to Airway Maintenance Devices: Proseal LMA V/S IGEL Airway
Hemodynamic stress responses to tracheal intubation can precipitate adverse cardiovascular events in patients. In principal, techniques that avoid or minimise oropharyngolaryngeal stimulation might attenuate the hemodyna...
Pelvic Ewing’s Sarcoma Presenting with Adnexal Mass in an Adolescent Girl- A Case Report
Adnexal masses are frequently observed finding in women attending gynecological OPD. An adnexal mass may be found in females of all ages- infants to elderly. The reported prevalence varies widely depending upon the popul...
Oral Submucous Fibrosis- A Review on Clinical Presentation, Histology, Epidemiology, Aetiology, Pathogenesis, Malignanat Potential and Management
Oral submucous fibrosis (OSMF) is a chronic, devastating disease characterised by juxtaepithelial fibrosis of the oral cavity. (1) Oral submucous fibrosis (OSMF) is a premalignant condition caused by betel chewing. It is...
A Case Report of Hypomagnesemia in Wernicke’s Encephalopathy
Magnesium is the second most abundant intracellular divalent cation in the body. Hypomagnesemia is a possible source of Wernicke’s encephalopathy, as it plays a role of cofactor in the phosphorylation of thiamine.1,2 Alc...
To Study the Intraocular Pressure and Blood Pressure Changes in Pre and Post-Menopausal Indian Women
Normal Intraocular pressure (IOP) is an essential prerequisite for the eye to serve its function as a light gathering and transducer organ. Various physiological factors which include age, gender and hormonal variations...